Document Detail

Accuracy of prenatal diagnosis in a tertiary fetal medicine unit.
MedLine Citation:
PMID:  19182842     Owner:  NLM     Status:  MEDLINE    
AIMS: To establish the accuracy of prenatal diagnosis in a tertiary referral fetal medicine unit by comparing those diagnoses made prenatally with diagnoses made at birth until discharge, and with postmortem information from cases that resulted in termination, intrauterine, or neonatal death. METHODS: All cases seen in the Fetal Medicine Unit between 1 June 2004 and 30 November 2005 were collected prospectively and sorted according to diagnosis. Relevant outcome data for these pregnancies were collected including postmortem information. RESULTS: 681 cases seen which accounted for 1219 visits. 198 were classified prenatally as a major abnormality, 46 cases minor, 56 with raised nuchal translucency, and 381 no abnormality. Outcome details were not available for analysis in two cases. Therefore 679 (99.7%) cases were available (711 out of 713 fetuses). Of the liveborns, 93.6% of the prenatal diagnoses were confirmed, 5.1% were resolved (predominantly soft markers), and 1.3% resulted in an additional major abnormality that had a significant clinical effect. Postmortem examinations were performed on 52% fetal or neonatal deaths with a normal or unknown karyotype. There was one new finding at postmortem that changed the fetal medicine diagnosis significantly. CONCLUSIONS: Accuracy of prenatal diagnosis in a tertiary fetal medicine unit is high. Parents and staff need to be aware that not all abnormalities will be detected prenatally, but inaccurate diagnosis is uncommon. Clinical indicators for benchmarking need to be developed.
Pippa M Kyle; Peter Coghlan; Jeannie Matthews; Rex de Ryke; Rosemary Reid
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-01-23
Journal Detail:
Title:  The New Zealand medical journal     Volume:  122     ISSN:  1175-8716     ISO Abbreviation:  N. Z. Med. J.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-02-10     Revised Date:  2010-10-22    
Medline Journal Info:
Nlm Unique ID:  0401067     Medline TA:  N Z Med J     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  50-61     Citation Subset:  IM    
Fetal Medicine Unit, Christchurch Women's Hospital/University of Otago, Christchurch, New Zealand.
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MeSH Terms
Congenital Abnormalities / diagnosis*,  embryology
Diagnostic Errors / statistics & numerical data*
Fetal Death / epidemiology
Fetal Diseases / diagnosis
Infant Mortality
Infant, Newborn
Nuchal Translucency Measurement
Prenatal Diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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