| Accuracy of low-dose computed tomography coronary angiography using prospective electrocardiogram-triggering: first clinical experience. | |
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MedLine Citation:
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PMID: 18996954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate the accuracy of low-dose computed tomography coronary angiography (CTCA) using prospective ECG-triggering for the assessment of coronary artery disease (CAD). METHODS AND RESULTS: A total of 30 patients (19 males, 11 females, mean age 58.8 +/- 9.9 years) underwent low-dose CTCA and invasive coronary angiography (CA) [median 2 days (0, 41)]. Before CT scanning, intravenous beta-blocker was administered in 18 of 30 patients as heart rate (HR) was >65 b.p.m., achieving a mean HR of 55.7 +/- 7.9 b.p.m. CAD was defined as coronary artery narrowing > or =50%, using CA as standard of reference. The estimated mean effective radiation dose was 2.1 +/- 0.7 mSv (range: 1.0-3.3), yielding 96.0% (383/399) of evaluable segments. On an intention-to-diagnose-base, all non-evaluative segments were included in the analysis. Vessels with a non-evaluative segment and no further finding were censored as false positive. Patient-based analysis revealed sensitivity, specificity, positive predictive value, and negative predictive value of 100, 83.3, 90.0, and 100%, respectively. The respective values per vessel were 100, 88.9, 85.7, and 100%, respectively. CONCLUSION: Prospective ECG-triggering allows low-dose CTCA and provides high diagnostic accuracy in the assessment of CAD in patients with stable sinus rhythm and a low heart rate. |
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Authors:
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Bernhard A Herzog; Lars Husmann; Nina Burkhard; Oliver Gaemperli; Ines Valenta; Fuminari Tatsugami; Christophe A Wyss; Ulf Landmesser; Philipp A Kaufmann |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-07 |
Journal Detail:
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Title: European heart journal Volume: 29 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-01-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 3037-42 Citation Subset: IM |
Affiliation:
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Cardiovascular Center, Raemistrasse 100, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Artifacts Coronary Angiography / methods*, standards Coronary Artery Disease / physiopathology, radiography* Electrocardiography / methods Female Heart Rate / physiology, radiation effects* Humans Male Middle Aged Prospective Studies Radiation Dosage Radiographic Image Enhancement Sensitivity and Specificity Tomography, X-Ray Computed / methods* Treatment Outcome |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2008 Dec;29(24):2955-6
[PMID:
19004843
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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