Document Detail

Accuracy of low-dose computed tomography coronary angiography using prospective electrocardiogram-triggering: first clinical experience.
MedLine Citation:
PMID:  18996954     Owner:  NLM     Status:  MEDLINE    
AIMS: To evaluate the accuracy of low-dose computed tomography coronary angiography (CTCA) using prospective ECG-triggering for the assessment of coronary artery disease (CAD). METHODS AND RESULTS: A total of 30 patients (19 males, 11 females, mean age 58.8 +/- 9.9 years) underwent low-dose CTCA and invasive coronary angiography (CA) [median 2 days (0, 41)]. Before CT scanning, intravenous beta-blocker was administered in 18 of 30 patients as heart rate (HR) was >65 b.p.m., achieving a mean HR of 55.7 +/- 7.9 b.p.m. CAD was defined as coronary artery narrowing > or =50%, using CA as standard of reference. The estimated mean effective radiation dose was 2.1 +/- 0.7 mSv (range: 1.0-3.3), yielding 96.0% (383/399) of evaluable segments. On an intention-to-diagnose-base, all non-evaluative segments were included in the analysis. Vessels with a non-evaluative segment and no further finding were censored as false positive. Patient-based analysis revealed sensitivity, specificity, positive predictive value, and negative predictive value of 100, 83.3, 90.0, and 100%, respectively. The respective values per vessel were 100, 88.9, 85.7, and 100%, respectively. CONCLUSION: Prospective ECG-triggering allows low-dose CTCA and provides high diagnostic accuracy in the assessment of CAD in patients with stable sinus rhythm and a low heart rate.
Bernhard A Herzog; Lars Husmann; Nina Burkhard; Oliver Gaemperli; Ines Valenta; Fuminari Tatsugami; Christophe A Wyss; Ulf Landmesser; Philipp A Kaufmann
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-07
Journal Detail:
Title:  European heart journal     Volume:  29     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  3037-42     Citation Subset:  IM    
Cardiovascular Center, Raemistrasse 100, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
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MeSH Terms
Coronary Angiography / methods*,  standards
Coronary Artery Disease / physiopathology,  radiography*
Electrocardiography / methods
Heart Rate / physiology,  radiation effects*
Middle Aged
Prospective Studies
Radiation Dosage
Radiographic Image Enhancement
Sensitivity and Specificity
Tomography, X-Ray Computed / methods*
Treatment Outcome
Comment In:
Eur Heart J. 2008 Dec;29(24):2955-6   [PMID:  19004843 ]

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