Document Detail


Accuracy of fetal fibronectin to predict preterm birth in twin gestations with symptoms of labor.
MedLine Citation:
PMID:  17470586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate accuracy of fetal fibronectin testing to predict preterm birth in twin gestations with symptoms of preterm labor. METHODS: We reviewed charts of all patients with twin gestations who underwent fetal fibronectin testing and presented with complaints of preterm labor between January 1, 2000, and June 30, 2004. We also reviewed the charts of all singleton gestations with similar complaints that had fetal fibronectin testing between January 1, 2000, and December 31, 2001. All samples were processed using a rapid fetal fibronectin detection system. We calculated the sensitivity, specificity, positive predictive value, and negative predictive value of fetal fibronectin testing in singleton and twin gestations in predicting delivery within 14 days of testing. RESULTS: Four hundred twenty-nine singletons and 87 twins met the inclusion criteria. The birth rate before 34 weeks of gestation for singletons was 3.5% compared with the rate of twin pregnancies of 28.7%. Fetal fibronectin predicted delivery within 14 days of testing with a sensitivity, specificity, and positive and negative predictive values in singleton gestations of 82%, 90%, 17%, and 99%, respectively. In twin gestations, fetal fibronectin predicted delivery within 14 days of testing with a sensitivity, specificity, and positive and negative predictive values of 71%, 74%, 19%, and 97%, respectively. CONCLUSION: As noted in singleton pregnancies, fetal fibronectin testing in twins has a high negative predictive value. Fetal fibronectin evaluation may be a useful tool in screening twins with symptoms of preterm labor, because a negative result places these women at a low risk for delivering within 2 weeks of testing.
Authors:
Emily Singer; Sylvia Pilpel; Fadi Bsat; Michael Plevyak; Andrew Healy; Glenn Markenson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  109     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-01     Completed Date:  2007-06-14     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1083-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology and Division of Maternal Fetal Medicine, Baystate Medical Center, Springfield, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fibronectins / metabolism*
Humans
Predictive Value of Tests
Pregnancy
Premature Birth / diagnosis*,  metabolism
Regression Analysis
Retrospective Studies
Sensitivity and Specificity
Twins*
Vagina / metabolism
Chemical
Reg. No./Substance:
0/Fibronectins

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