| Accuracy and cut-off point selection in three-class classification problems using a generalization of the Youden index. | |
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MedLine Citation:
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PMID: 20809485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We study properties of the index J(3), defined as the accuracy, or the maximum correct classification, for a given three-class classification problem. Specifically, using J(3) one can assess the discrimination between the three distributions and obtain an optimal pair of cut-off points c(1)<c(2) in the sense that the sum of the correct classification proportions will be maximized. It also serves as the generalization of the Youden index in three-class problems. Parametric and non-parametric approaches for estimation and testing are considered and methods are applied to data from an MRS study on human immunodeficiency virus (HIV) patients. |
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Authors:
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Christos T Nakas; Todd A Alonzo; Constantin T Yiannoutsos |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Statistics in medicine Volume: 29 ISSN: 1097-0258 ISO Abbreviation: Stat Med Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-03-01 Revised Date: 2011-12-15 |
Medline Journal Info:
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Nlm Unique ID: 8215016 Medline TA: Stat Med Country: England |
Other Details:
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Languages: eng Pagination: 2946-55 Citation Subset: IM |
Affiliation:
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Laboratory of Biometry, University of Thessaly, Fytokou Str, N. Ionia, 384 46 Magnesia, Greece. cnakas@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS Dementia Complex
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diagnosis Aspartic Acid / analogs & derivatives, analysis Bias (Epidemiology) Biological Markers / analysis* Biostatistics / methods* Classification / methods* Computer Simulation Creatine / analysis Data Interpretation, Statistical Diagnostic Tests, Routine / statistics & numerical data* Humans Magnetic Resonance Spectroscopy Models, Statistical ROC Curve Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
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NS036524/NS/NINDS NIH HHS; R01 NS036524-05/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 997-55-7/N-acetylaspartate |
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