| Accuracy considerations when using early (four- or six-hour) radioactive iodine uptake to predict twenty-four-hour values for radioactive iodine dosage in the treatment of Graves' disease. | |
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MedLine Citation:
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PMID: 11041455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although literature has offered methods to predict 24-hour radioactive iodine uptake values from early (4- to 6-hour) measurements, the resultant dosage errors have not been examined. Potential errors include underdosage, overdosage, and a failure to recognize rapid turnover patients (early-to-late uptake ratios > or = 1) who are at high risk for treatment failure and full-body radiation exposure. We developed and tested a novel method for minimizing error involved in using a single early uptake measurement to derive late uptake. From a retrospective analysis of 203 Graves' disease patients, receiver operating characteristic (ROC) curve analysis enabled us to identify patients likely to experience rapid turnover and therefore should receive 24-hour studies. Twenty-four-hour uptake measurements are necessary with 77% or more 4-hour uptake values and 80% or more 6-hour values. After eliminating these patients, we developed linear regression equations to predict the 24-hour uptake from 4-hour (n = 61) and 6-hour (n = 22) rule groups, testing their efficacy on separate 4-hour (n = 61) and 6-hour (n = 21) patient groups. We also used our test population to measure error in four early-to-late uptake conversion formulas presented in the literature. Error involved in these predictions ranged from a 10.6% overestimate for 4-hour calculations to a 5.9% underestimate for 6-hour calculations. When applied to two dosage formulas incorporating gland size, absorbed dose, and 24-hour uptake, average dosage error was 7%. In comparison to the other sources of error radioactive iodine (131I) dosimetry, potential error in predicting 24-hour uptake from 4- or 6-hour uptake values is low. |
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Authors:
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L F Morris; A D Waxman; G D Braunstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: 10 ISSN: 1050-7256 ISO Abbreviation: Thyroid Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2001-01-17 Completed Date: 2001-02-01 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 779-87 Citation Subset: IM |
Affiliation:
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Department of Medicine and Nuclear Medicine, Cedars-Sinai Medical Center-UCLA School of Medicine, Los Angeles, California 90048, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Graves Disease
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pathology,
radiotherapy* Humans Iodine Radioisotopes / pharmacokinetics*, therapeutic use* Linear Models Mathematics ROC Curve Radiotherapy Dosage Sensitivity and Specificity Thyroid Gland / pathology |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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