Document Detail

Accuracy of combined clinical findings and fine needle aspiration cytology for the diagnosis in palpable breast tumors.
MedLine Citation:
PMID:  10972058     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A prospective study to evaluate the confidence level and predictive value of the fine needle aspiration biopsy was performed in the Oncology Service, "Hospital 20 de Noviembre, ISSSTE", Mexico City. MATERIAL AND METHODS: The cases with a palpable breast tumor, histologically confirmed who presented from 1992 to 1994 were included. One aspirate was done in each patient and these were reviewed by the same pathologist. We determined sensitivity, specificity and predictive value of the test. Age, border characteristics, size and mobility of the tumor were evaluated by Bayesian analysis. RESULTS: From 213 aspirates, 199 were elegible for diagnosis, 98 (46%) had a diagnosis of carcinoma, 13 were acellular and one suggestive. The acellular diagnoses were considered negative and suggestive positive, for analysis purposes. Mean age and tumor size were: 46.6 years (range 14-90) and 3.7 cm. (range 1-13) respectively. Sensitivity (0.932), specificity (0.973) and positive predictive value (96.9%) were estimated. We observed a high probability of true positive [P(D+/T+)] > 0.8 results in patients between 40 and 60 years of age, irregular borders, size > 2 cm and fixed lesions. CONCLUSIONS: The test has a high confidence level and in presence of two or more of the clinical factors mentioned, definitive decisions regarding treatment could be taken, without need of histologic confirmation.
J F Carrillo; M F Mendivil; J R Domínguez; G E de Obaldía; R Esparza
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición     Volume:  51     ISSN:  0034-8376     ISO Abbreviation:  Rev. Invest. Clin.     Publication Date:    1999 Nov-Dec
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-10-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421552     Medline TA:  Rev Invest Clin     Country:  MEXICO    
Other Details:
Languages:  eng     Pagination:  333-9     Citation Subset:  IM    
Division of Surgery, Instituto Nacional de Cancerología (INCan), Mexico City.
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MeSH Terms
Aged, 80 and over
Biopsy, Needle / standards*
Breast Neoplasms / pathology*
False Negative Reactions
False Positive Reactions
Middle Aged
Prospective Studies
Reproducibility of Results
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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