| Accuracy of the S100β protein as a marker of brain damage in traumatic brain injury. | |
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MedLine Citation:
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PMID: 22149446 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: This study tested the hypothesis that S100β is a useful screening tool for detecting intracranial lesion (IL) in patients with a normal level of consciousness after traumatic brain injury (TBI). Methods: One hundred and forty-three post-TBI patients without a decrease in consciousness (GCS = 15) and with at least one neurological symptom (e.g. transitory loss of consciousness, amnesia, headache, dizziness or vomiting) were prospectively included. A blood sample was drawn at 6-hours post-TBI. A routine CT scan was obtained within 24 hours post-injury. Diagnostic properties of S100β for IL prediction in CT scan findings were tested using ROC-analysis. Results: A total of 15 patients (10.5%) had IL. Serum levels were significantly higher in these patients. Significant differences were found between S100β levels and CT scan findings (p = 0.007). ROC-analysis showed that S100β is a useful tool for detecting the presence of IL in CT scans (p = 0.007). In this series, the best cut-off for S100β is 0.130 µg L(-1), with 100% sensitivity and 32.81% specificity. Conclusion: Within the first 6 hours post-TBI, serum S100β seems to be an effective biochemical indicator of IL in patients without a decrease in consciousness. These results indicate that higher S100β cut-off values substantially improve the clinical relevance of this protein. |
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Authors:
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J J Egea-Guerrero; J Revuelto-Rey; F Murillo-Cabezas; M A Muñoz-Sánchez; A Vilches-Arenas; P Sánchez-Linares; J M Domínguez-Roldán; J León-Carrión |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain injury : [BI] Volume: 26 ISSN: 1362-301X ISO Abbreviation: Brain Inj Publication Date: 2012 |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710358 Medline TA: Brain Inj Country: England |
Other Details:
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Languages: eng Pagination: 76-82 Citation Subset: IM |
Affiliation:
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NeuroCritical Care Unit . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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