Document Detail


Accuracy and Reproducibility of Seven Brands of Small-Volume Syringes Used for Intraocular Drug Delivery.
MedLine Citation:
PMID:  23799792     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Little is known about the accuracy and precision of syringes used to deliver small-volume intravitreal injection of medication. The authors investigated the accuracy and reproducibility of seven brands of small-volume syringes used for intravitreal injection.
MATERIALS AND METHODS: This experimental laboratory investigation compared EXELint 1cc TB, BD Luer-lok, BD 1cc TB, Kendall Monoject TB, Nipro TB, Terumo 1cc, and Terumo 0.5 cc syringes. A calibrated Pipetman served as a control. One hundred syringes of each brand delivered 0.05 mL and 0.10 mL distilled water onto a balance. One-sample t-test (P < .01) compared delivered and intended volumes.
RESULTS: The Nipro TB was the most accurate syringe at 0.05 mL. All other brands over-delivered the target volume. At 0.10 mL, the BD Luer-lok and Nipro TB were the most accurate. BD Luer-lok over-delivered while Nipro TB under-delivered, but these deviations were not statistically significant. The Pipetman control was the most accurate and reproducible device at both volumes.
CONCLUSION: Nipro TB was the most accurate syringe at both volumes. Terumo 0.5 cc gave the most reproducible results but lacked accuracy. These findings may affect treatment efficacy and explain variability in treatment responses. Industry-standardized delivery devices may increase the accuracy and reproducibility of medication delivery. [Ophthalmic Surg Lasers Imaging Retina. 2013;44:xxx-xxx.].
Authors:
Kapil M Sampat; Jeremy D Wolfe; Mona K Shah; Sunir J Garg
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-02
Journal Detail:
Title:  Ophthalmic surgery, lasers & imaging retina     Volume:  -     ISSN:  2325-8179     ISO Abbreviation:  Ophthalmic Surg Lasers Imaging Retina     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-6-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101599215     Medline TA:  Ophthalmic Surg Lasers Imaging Retina     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-5     Citation Subset:  -    
Copyright Information:
Copyright 2013, SLACK Incorporated.
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