| Accuracy and Reproducibility of Automated Drusen Segmentation in Eyes with Non-neovascular Age-Related Macular Degeneration. | |
| | |
MedLine Citation:
|
PMID: 23150629 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate the accuracy and reproducibility of drusen quantification by an automated drusen segmentation algorithm in spectral domain optical coherence tomography (SD-OCT) images of eyes with non-neovascular age-related macular degeneration (AMD). METHODS: Drusen segmentation was performed using both a commercial automated algorithm (Cirrus OCT RPE analysis tool) and manual segmentation in 44 eyes of 30 subjects with dry AMD who underwent volume OCT scanning. The drusen (space between outer RPE layer and Bruch's membrane) was segmented automatically using an automated RPE tool and manually by 3D-OCTOR. Drusen area and volume were calculated in all eyes. Age and visual acuity data was also collected. Reproducibility of manual and automated measurements was assessed by intraclass correlation (ICC). RESULTS: The mean age of subjects was 78.24 (± 9.4, range; 56 - 97 years). Mean Log MAR visual acuity was 0.4 (Snellen equivalent ~ 20/50) (SD: 0.40; range: 0 - 1.3). The mean (SD) drusen area was 5.05 (3.67) mm2 with manual segmentation and 4.66 (3.51) mm2 with the automated RPE tool; the absolute difference was 2.63 (2.5) mm2. Mean drusen volume was 1.49 (0.42) mm3 with manual segmentation and 1.42 (0.43) mm3 with the automated RPE tool; the absolute difference was 1.42 (0.43) mm3. Agreement between manual and automated measurements of drusen volume (highest ICC=0.95) was better than the agreement for drusen area (ICC=0.65). CONCLUSION: The quantification of drusen area and volume using an automated RPE yielded better agreement for volume than for area when compared with human expert manual segmentation. Using this software, drusen volume measurements may be a useful tool for quantifying drusen burden in clinical trials and clinical practice. |
| | |
Authors:
|
Muneeswar Gupta Nittala; Humberto Ruiz-Garcia; Srinivas R Sadda |
Related Documents
:
|
718819 - Aspiration from the vitreous of a non-magnetic foreign body. 786229 - Intraocular copper foreign bodies. use of dexamethasone to suppress inflammation. 23175879 - Pattern of conjunctival masses seen at guinness eye centre luth idi-araba. 21630179 - Baby sleeping bag and conventional bedding conditions - comparative investigations by i... 6328849 - Occupational eye injuries in finland. 9199749 - Oedipism. 20712869 - Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a ... 21474969 - Corneal hysteresis in normal subjects and in patients with primary open-angle glaucoma ... 22807989 - Correction: research on the stability of a rabbit dry eye model induced by topical appl... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-13 |
Journal Detail:
|
Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Ophthalmology, University of Southern California, Doheny Eye Institute, Keck School of Medicine, Los Angeles, CA, United States. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunoproteomic analysis of potential serum biomarker candidates in human glaucoma.
Next Document: Phosphatidic Acid Regulates Microtubule Organization by Interacting with MAP65-1 in Response to Salt...