Document Detail


Accuracy of Doppler-Derived Indices in Predicting Pulmonary Vascular Resistance in Children With Pulmonary Hypertension Secondary to Congenital Heart Disease With Left-to-Right Shunting.
MedLine Citation:
PMID:  24150686     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study aimed to evaluate the accuracy of Doppler echocardiography-derived indices in children with pulmonary hypertension secondary to congenital heart disease with left-to-right shunting. Doppler-derived indices including the acceleration time corrected (AcTc), deceleration time corrected, deceleration index, peak velocity, heart-rate-corrected inflection time (InTc), and a new index (the acceleration slope [Acc = peak flow velocity/AcTc]) were measured from the pulmonary artery (PA) systolic flow curve before and after 100 % oxygen administration in the main, left, and right PAs of 33 children. The acquired data were compared between low and high pulmonary vascular resistance (PVR) groups and between responders and nonresponders to the vasoreactivity test. The AcTc values differed significantly between the low and high PVR groups before and after oxygen administration in the main (P = 0.032 and <0.001, respectively), right (P = 0.011 and <0.001, respectively), and left (P < 0.001 and <0.001, respectively) PAs. The AcTc cutoff point in the main PA was 3.44 before oxygen administration (81 % sensitivity and 91 % specificity). The InTc in the main PA and its changes differed significantly between the low and high PVR groups before and after oxygen administration and between the responders and nonresponders (P = 0.016, 0.046, and 0.021, respectively). The velocity changes of the PA in the main PA differed significantly between the responders and nonresponders to oxygen administration (P < 0.001). The Acc and its changes differed significantly between the low and high PVR groups after oxygen administration and between the responders and nonresponders to oxygen administration (P = 0.044 and 0.006, respectively). Doppler echocardiographic examination using PA systolic flow indices in addition to PA reactivity testing is a promising technique for assessing PVR in children with congenital heart disease.
Authors:
Avisa Tabib; Mohammad Rafie Khorgami; Mahmoud Meraji; Negar Omidi; Yalda Mirmesdagh
Related Documents :
16960456 - The craniospinal venous system.
21138226 - Improved pulmonary function after concave rib resection and posterior instrumentation f...
2339006 - Acupuncture meridians and radiotracers.
16463836 - Evidence for the importance of extracranial venous flow in patients with idiopathic int...
20016906 - Assessment of vascular invasion by bone and soft tissue tumours of the limbs: usefulnes...
9363166 - Idiopathic pulmonary fibrosis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-23
Journal Detail:
Title:  Pediatric cardiology     Volume:  -     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Heart Valve Disease Research Center, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of Fontan Fenestration on Regional Venous Oxygen Saturation During Exercise: Further Insights...
Next Document:  Characterization and differentiation potential of rabbit mesenchymal stem cells for translational re...