Document Detail

Accuracy of death certificates in COPD: analysis from the TORCH trial.
MedLine Citation:
PMID:  20486816     Owner:  NLM     Status:  MEDLINE    
The Towards a Revolution in COPD Health (TORCH) trial was an international clinical trial of chronic obstructive pulmonary disease (COPD) patients where cause of death was assigned by an independent committee. Comparison of death certificate data and adjudicated cause of death allows a unique opportunity to determine death certificate accuracy and frequency of COPD listing on death certificates of COPD patients. In this analysis, the authors determine the concordance between adjudicated cause of death and primary and secondary cause of death from death certificates. In 317 (80%) of informative deaths, the primary or secondary cause of death from certificates agreed with adjudicated cause of death. Only 229 (58%) of death certificates in these COPD patients listed COPD on the certificate. COPD was not listed on the death certificate in 21% of deaths adjudicated to be caused by COPD exacerbation. Compared with pulmonary causes, the listing of COPD on certificates occurred with less frequency than cardiovascular, cancer and other categories of death. The combined primary and secondary listing on death certificates has good concordance with actual cause of death. COPD is under-reported on death certificates, and this under-reporting is more frequent when the primary cause of death is not pulmonary.
M Bradley Drummond; Robert A Wise; Matthias John; Michael T Zvarich; Lorcan P McGarvey
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  COPD     Volume:  7     ISSN:  1541-2563     ISO Abbreviation:  COPD     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101211769     Medline TA:  COPD     Country:  England    
Other Details:
Languages:  eng     Pagination:  179-85     Citation Subset:  IM    
Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.
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MeSH Terms
Administration, Inhalation
Albuterol / administration & dosage,  analogs & derivatives
Androstadienes / administration & dosage
Bronchodilator Agents / administration & dosage
Cause of Death / trends
Data Interpretation, Statistical
Death Certificates*
Dose-Response Relationship, Drug
Double-Blind Method
Drug Therapy, Combination
Pulmonary Disease, Chronic Obstructive / drug therapy,  mortality*
Reg. No./Substance:
0/Androstadienes; 0/Bronchodilator Agents; 18559-94-9/Albuterol; 89365-50-4/salmeterol; 90566-53-3/fluticasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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