| Accuracy of anthropometric indexes of obesity to predict diabetes mellitus type 2 among men and women with hypertension. | |
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MedLine Citation:
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PMID: 20885370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Anthropometric measurements and indexes that assess excess of adiposity are associated with cardiovascular risk factors, and predict diabetes mellitus. METHODS: This cross-sectional study reported the performance of adiposity indexes to detect or turn diabetes unlikely in patients with hypertension. Patients with hypertension (blood pressure (BP) ≥140/90 mm Hg or antihypertensive drug use) aged 18-80 years, being 150 men and 332 women, had weight, height, waist circumference (WC), hip circumference, body mass index (BMI), waist-hip ratio (WHR), waist-to-height ratio (WHtR), and waist-to-square height ratio (WHt(2)R) calculated. Diabetes was diagnosed by fasting blood glucose ≥126 mg/dl or antidiabetic drug use (23% of the sample). RESULTS: All anthropometric indexes were associated with diabetes in a modified Poisson regression, adjusting for age, smoking, and physical activity, in women, but not in men. In men, only the area under the receiver-operating characteristic curve (AUC) for WHR was statistically associated with diabetes (0.67, 95% confidence interval (CI) 0.57-0.77). A cutoff of ≥0.95 had sensitivity of 84.6% (73.3-95.9) and negative post-test probability of 12.8% (3.2-22.4). Among women, WC >88 cm, WHR ≥0.85, and WHtR > 0.54 had sensitivity >93% and negative post-test probability <7.5%. CONCLUSIONS: WHR ≥0.85, WC >88.0 cm, and WHtR >0.54 for women and WHR ≥0.95 for men are highly suggestive of diabetes among this population of hypertensive patients. Indexes below these cutoffs turn diabetes unlikely in this context. The investigation of reproducibility of this performance in other outpatient clinics is warranted. |
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Authors:
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Aline Marcadenti; Sandra C Fuchs; Leila B Moreira; Mario Wiehe; Miguel Gus; Flavio D Fuchs |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-30 |
Journal Detail:
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Title: American journal of hypertension Volume: 24 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-20 Completed Date: 2011-05-03 Revised Date: 2011-06-30 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 175-80 Citation Subset: IM |
Affiliation:
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Hospital de Clinicas de Porto Alegre, National Institute for Science and Technology for Health Technology Assessment, Centro de Pesquisas, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anthropometry* Antihypertensive Agents / therapeutic use Blood Glucose / analysis Blood Pressure Body Mass Index Brazil / epidemiology Chi-Square Distribution Cross-Sectional Studies Diabetes Mellitus, Type 2 / blood, diagnosis*, drug therapy, epidemiology* Female Humans Hypertension / diagnosis, drug therapy, epidemiology*, physiopathology Hypoglycemic Agents / therapeutic use Male Middle Aged Obesity / diagnosis*, epidemiology* Predictive Value of Tests ROC Curve Regression Analysis Risk Assessment Risk Factors Sensitivity and Specificity Sex Factors Waist Circumference Waist-Hip Ratio |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Blood Glucose; 0/Hypoglycemic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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