Document Detail

Accuracy of 3 T MR angioraphy in vertebral artery stenosis and coincidence with other cerebrovascular stenoses.
MedLine Citation:
PMID:  20107775     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Ostium of vertebral artery (VA) is a common site of pseudostenosis on contrast-enhanced MR angiography (CE-MRA). The purpose of this study was to determine the diagnostic accuracy of CE-MRA at 3 T in the evaluation of ostial stenosis of VA and to find associated coincidental stenoses using logistic regression analysis.
METHODS: One hundred and thirty-five VA ostial regions from 72 patients who received CE-MRA of neck vessels, intracranial time of flight (TOF) MRA, and digital subtraction angiography (DSA) were retrospectively reviewed. The sensitivity and specificity of the CE-MRA in detection of ostial stenosis were calculated with reference standard of DSA. Ostial stenosis on MRA was correlated with coincidental lesions in intracranial and cervical arteries by logistic regression analysis.
RESULTS: The sensitivity and specificity of the CE-MRA were 100% and 80.4% for detection of significant stenosis. In case of significant stenoses, CE-MRA showed a tendency of overestimation with a false-positive rate of 52.5%. Logistic regression analysis showed that the stenoses of middle cerebral artery (MCA) on TOF MRA was associated with significant stenoses of VA ostia (OR = 5.84, 95% confidence intervals 1.41-24.17).
CONCLUSION: CE-MRA is sensitive in detection of VA ostial stenosis although it has high false-positive rate. True positive ostial stenosis should be considered in cases of coincidental stenoses of MCA on TOF MRA.
Hyun Seok Choi; Dong Ik Kim; Dong Joon Kim; Jinna Kim; Eun Soo Kim; Seung-Koo Lee
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Publication Detail:
Type:  Journal Article     Date:  2010-01-28
Journal Detail:
Title:  Neuroradiology     Volume:  52     ISSN:  1432-1920     ISO Abbreviation:  Neuroradiology     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  893-8     Citation Subset:  IM    
Department of Radiology, Yonsei University College of Medicine, 250 Seongsanro, Seodaemungu, Seoul, 120-752, Korea.
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MeSH Terms
Cerebrovascular Disorders / complications*,  pathology*
Magnetic Resonance Angiography / methods*
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Vertebrobasilar Insufficiency / complications*,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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