| Accuracy of 18F-FDG-PET/CT for staging of oral squamous cell carcinoma. | |
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MedLine Citation:
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PMID: 18767178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study prospectively assessed 2-[F18]-fluoro-2-deoxy-D-glucose-positron emission tomography (18F-FDG-PET)/CT (PET/CT) in oral squamous cell carcinoma. METHODS: Twenty-three patients completed preoperative TNM staging (CT, MR, whole-body fusion imaging PET/CT). In patients who underwent surgical therapy (19 of 23), TNM staging based on PET/CT scan was compared with pTNM. RESULTS: PET/CT correctly staged 16 of 19 primary tumors (accuracy 84.2%, sensitivity 84.2%, positive predictive value 100%) and correctly ruled out bone invasion in 3 patients with false-positive results according to CT and/or MR. PET/CT incorrectly identified neck involvement in 5 of 15 patients (3 false positives, 2 false negatives) who underwent neck dissection (accuracy 66.7%, specificity 76.9%, negative predictive value 83.3%). False-negative cases showed a nodal size not exceeding 10 mm. One patient with a bronchial synchronous primary tumor was identified. CONCLUSION: PET/CT scan showed good accuracy in determining the extension and/or depth of invasion of the primary tumor. Nevertheless, PET/CT was not accurate to rule out nodal metastases. |
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Authors:
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Monica Pentenero; Angela Cistaro; Mario Brusa; Maria Maddalena Ferraris; Carla Pezzuto; Riccardo Carnino; Edro Colombini; Maria Consuelo Valentini; Luca Giovanella; Giuseppe Spriano; Sergio Gandolfo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Head & neck Volume: 30 ISSN: 1097-0347 ISO Abbreviation: Head Neck Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2009-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
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Languages: eng Pagination: 1488-96 Citation Subset: IM |
Copyright Information:
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(c) 2008 Wiley Periodicals, Inc. Head Neck, 2008. |
Affiliation:
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Oral Medicine and Oral Oncology Section, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy. monica.pentenero@unito.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / pathology, radiography*, radionuclide imaging*, surgery Female Fluorodeoxyglucose F18 / diagnostic use* Humans Italy Male Middle Aged Mouth Neoplasms / pathology, radiography*, radionuclide imaging*, surgery Neck Dissection Neoplasm Staging / methods Positron-Emission Tomography / methods* Predictive Value of Tests Prospective Studies Radiopharmaceuticals / diagnostic use Sensitivity and Specificity Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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