| Accumulation of trinitrotoluene (TNT) in aquatic organisms: part 1--Bioconcentration and distribution in channel catfish (Ictalurus punctatus). | |
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MedLine Citation:
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PMID: 15667836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Little is currently known regarding the toxicokinetics of TNT in fish. In the present study, the bioconcentration and distribution of trinitrotoluene (TNT) and TNT biotransformation products was investigated in juvenile channel catfish by exposing catfish to 14C-labeled TNT in water. Uptake experiments showed relatively fast rates (k(u)=10.1 ml g(-1) h(-1)) for TNT from the water; however, bioconcentration factors for TNT were low (0.79 ml g(-1)) due to rapid biotransformation and potential elimination of TNT. Accumulation of extractable radioactivity (TNT and all extractable biotransformation products) was much greater (BCF=10.5 ml g(-1)) than that for parent compound. TNT (parent compound) bioconcentrated to the greatest extent in the gills of the fish, while total radioactivity bioconcentrated to the greatest extent in the viscera. Residual portions of the fish that contained muscle and skin had lower concentrations of TNT than the whole fish, indicating that ingestion of fish fillets would result in decreased exposure to human consumers. Although the bioconcentration potential of TNT is very low, future research needs to be conducted to identify the biotransformation products that make up most of the radioactivity in exposed fish and evaluate their potential to promote toxicity. |
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Authors:
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David R Ownby; Jason B Belden; Guilherme R Lotufo; Michael J Lydy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemosphere Volume: 58 ISSN: 0045-6535 ISO Abbreviation: Chemosphere Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-01-25 Completed Date: 2005-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0320657 Medline TA: Chemosphere Country: England |
Other Details:
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Languages: eng Pagination: 1153-9 Citation Subset: IM |
Affiliation:
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Fisheries and Illinois Aquaculture Center and Department of Zoology, Southern Illinois University, Carbondale, Illinois 62901-6511, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Radioisotopes Drug Stability Gills / chemistry, metabolism Ictaluridae / metabolism* Metabolic Clearance Rate Muscles / chemistry Trinitrotoluene / analysis, metabolism*, pharmacokinetics Viscera / chemistry, metabolism Water Pollutants, Chemical / analysis, metabolism*, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Water Pollutants, Chemical; 118-96-7/Trinitrotoluene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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