Document Detail


Accumulation of silver from drinking water into cerebellum and musculus soleus in mice.
MedLine Citation:
PMID:  12604179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In spite of the general toxicity, ecotoxicity and sparsely known metabolism of silver, WHO allows silver ions (Ag) up to 0.1 mg/l in drinking water disinfection. In order to determine the accumulation and distribution of silver in a mammalian body, mice were given for 1 and 2 weeks drinking water containing a 3-fold lower concentration, namely 0.03 mg/l silver ions as silver nitrate labelled with 110mAg. The silver concentrations in different tissues were analysed by gamma radioactivity. The saturation of tissues with silver seems to occur quickly, as there were no statistical differences between silver contents of mice tissues in spite of the study design that mice were administered silver for 1 or 2 weeks. The highest concentrations were found in musculus soleus (m. soleus), cerebellum, spleen, duodenum, and myocardial muscle in the rank order. Concentrations of silver in musculus gastrocnemius (m. gastrocnemius) were found to correlate negatively with cerebrum and positively with blood and kidneys. The accumulation of silver into organs and tissues important in motor functions may be of relevance especially in emergency and catastrophe situations in which accurate motor functions may be critical. A re-evaluation of the present recommendations on the use of silver salts for disinfection of drinking water might be necessary.
Authors:
Kai H O Pelkonen; Helvi Heinonen-Tanski; Osmo O P Hänninen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  186     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-04-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Kuopio, POB 1627, FIN 70211 Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cerebellum / drug effects,  metabolism*
Drinking
Fresh Water
Male
Mice
Muscle, Skeletal / drug effects,  metabolism*
Silver Nitrate / pharmacokinetics*,  toxicity
Water Purification / standards
World Health Organization
Chemical
Reg. No./Substance:
7761-88-8/Silver Nitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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