Document Detail

Accumulation of silicone elastomer in regular dialysis.
MedLine Citation:
PMID:  6348733     Owner:  NLM     Status:  MEDLINE    
A retrospective autopsy study of 78 patients treated by some form of dialysis for chronic renal failure in Newcastle 1964-1981 showed that: 1) Particles resembling silicone elastomer were present in 48 per cent of 61 patients haemodialysed with the use of silicone rubber pump inserts but in none of the 11 treated by haemodialysis with other pump inserts or of the six treated by peritoneal dialysis alone; 2) The prevalence of these particles and their density increased with time on haemodialysis; 3) There was little evidence of a tissue reaction to the particles and no association between their presence and histological evidence of liver disease; 4) There was a higher incidence of clinical and biochemical evidence of liver disease in patients with silicone deposits than in those without. Although there are other possible explanations for this higher incidence of hepatic dysfunction it would be safer to assume that silicone particle spallation is not innocuous.
T Laohapand; E M Osman; A R Morley; M K Ward; D N Kerr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association     Volume:  19     ISSN:  0071-2736     ISO Abbreviation:  Proc Eur Dial Transplant Assoc     Publication Date:  1983  
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0355210     Medline TA:  Proc Eur Dial Transplant Assoc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  143-52     Citation Subset:  IM    
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MeSH Terms
Kidney Failure, Chronic / therapy*
Kidney Transplantation
Kidney, Artificial
Liver* / pathology
Microscopy, Electron, Scanning
Peritoneal Dialysis / adverse effects
Renal Dialysis* / adverse effects
Retrospective Studies
Silicone Elastomers*
Time Factors
Reg. No./Substance:
0/Silicone Elastomers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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