Document Detail


Accumulation of senescent cells in mitotic tissue of aging primates.
MedLine Citation:
PMID:  17116315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cellular senescence, a stress induced growth arrest of somatic cells, was first documented in cell cultures over 40 years ago, however its physiological significance has only recently been demonstrated. Using novel biomarkers of cellular senescence we examined whether senescent cells accumulate in tissues from baboons of ages encompassing the entire lifespan of this species. We show that dermal fibroblasts, displaying markers of senescence such as telomere damage, active checkpoint kinase ATM, high levels of heterochromatin proteins and elevated levels of p16, accumulate in skin biopsies from baboons with advancing age. The number of dermal fibroblasts containing damaged telomeres reaches a value of over 15% of total fibroblasts, whereas 80% of cells contain high levels of the heterochromatin protein HIRA. In skeletal muscle, a postmitotic tissue, only a small percentage of myonuclei containing damaged telomeres were detected regardless of animal age. The presence of senescent cells in mitotic tissues might therefore be a contributing factor to aging and age related pathology and provides further evidence that cellular senescence is a physiological event.
Authors:
Jessie C Jeyapalan; Mark Ferreira; John M Sedivy; Utz Herbig
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-11-20
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  128     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-15     Completed Date:  2007-04-20     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  36-44     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Cell Aging / physiology*
Cells, Cultured
Fibroblasts / cytology,  physiology*
Mitosis / physiology*
Papio
Grant Support
ID/Acronym/Agency:
F32 CA099388/CA/NCI NIH HHS; F32 CA099388-03/CA/NCI NIH HHS; P20 RR-15578/RR/NCRR NIH HHS; P20 RR015578-05/RR/NCRR NIH HHS; R01 AG016694/AG/NIA NIH HHS; R01 AG016694-05/AG/NIA NIH HHS
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