| Accumulation of plasmacytoid DC: Roles in disease pathogenesis and targets for immunotherapy. | |
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MedLine Citation:
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PMID: 20853492 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasmacytoid DC (pDC) secrete type I IFN in response to viruses and RNA/DNA/immunocomplexes. Type I IFN confer resistance to viral infections and promote innate and adaptive immune responses. pDC also produce cytokines and chemokines that influence recruitment and function of T cells and differentiation of B cells. Thus, pDC have been implicated both in protective immune responses and in induction of tolerance. In this Viewpoint, we discuss how the recruitment and accumulation of pDC may impact pathogenesis of several diseases and how pDC can be targeted for therapeutic interventions. |
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Authors:
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Melissa Swiecki; Marco Colonna |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: European journal of immunology Volume: 40 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2010-12-23 Revised Date: 2012-02-03 |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 2094-8 Citation Subset: IM |
Affiliation:
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Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity Animals B-Lymphocytes / immunology Cell Communication / immunology Cell Differentiation Cell Movement Dendritic Cells / immunology* Humans Immune Tolerance Immunity, Innate Immunotherapy* Interferon Type I / immunology, metabolism* Lymphocyte Activation T-Lymphocytes / immunology Virus Diseases / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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5T32 DK007296/DK/NIDDK NIH HHS; P30 DK056341-10/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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