Document Detail


Accumulation of oocytes from a few modified natural cycles to improve IVF results: a pilot study.
MedLine Citation:
PMID:  24077861     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the role of co-transfer of embryos derived from vitrified oocytes accumulated during the previous modified natural cycles and an embryo developed from the last one as an alternative to repetitive single embryo transfer ina fresh modified natural cycle.
METHODS: Thirty-six patients underwent ICSI procedure with three frozen natural oocytes supplemented by a fresh one obtained from the fourth modified natural cycle. Thirty-one controls received at least three consecutive single embryo transfer in a fresh modified natural cycle.
RESULTS: In the study group the oocyte retrieval, survival and total fertilization rate were 73.0 %, 78.1 %, and 64.5 %, respectively. Fifty-two embryos were transferred in 29 transfers. In the control group the oocyte retrieval and fertilization rate was 77.4 % and 83.7 %, respectively. Fifty single embryo transfers were performed. Of a total 14 pregnancies obtained in the study group 10 were defined as clinical and 4 as abortions. In the control group a total of 8 single clinical pregnancies and 2 miscarriages were encountered. The overall (20.0 % vs 48.2 %) and the clinical (16.0 % vs 34.4 %) pregnancy rate were significantly higher in the study group having cumulative embryo transfer following the oocyte accumulation.
CONCLUSIONS: These data demonstrate that the co-transfer of embryos derived from vitrified oocytes accumulated during the previous modified natural cycles and an embryo developed from the last fresh modified natural cycle assure an excellent clinical outcome with the overall and clinical pregnancy rate significantly higher compared to the repetitive single embryo transfer in a fresh modified natural cycle.
Authors:
Ermanno Greco; Katarzyna Litwicka; Cristiana Arrivi; Maria Teresa Varricchio; Daniela Zavaglia; Cecilia Mencacci; Maria Giulia Minasi
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  30     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2014-01-06     Completed Date:  2014-07-24     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1465-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Cryopreservation
Embryo Transfer / methods*
Female
Fertilization
Fertilization in Vitro*
Humans
Middle Aged
Oocytes / cytology*
Pilot Projects
Pregnancy
Sperm Injections, Intracytoplasmic*
Vitrification
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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