| Accumulation of membrane-bound melanosomes occurs in Langerhans cells of patients with the Leopard syndrome. | |
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MedLine Citation:
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PMID: 1424250 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Langerhans cells in the lentigines of four patients with the Leopard syndrome contained large membrane bound accumulations of melanin granules. Giant melanosomes were only seen in two patients. The patients had no immune-based symptoms relating to their lentigines. The Leopard Syndrome, also known as multiple lentigines syndrome, progressive cardiomyopathic lentiginosis, lentiginosis profusa syndrome and the cardiocutaneous syndrome, refers to an inherited abnormality of the skin, often associated with cardiomyopathy. The aetiology of the condition is so far unknown and the penetrance is variable. Here we describe electron microscopical findings of large accumulations of melanin within Langerhans cells. |
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Authors:
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P R Fryer; F M Pope |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental dermatology Volume: 17 ISSN: 0307-6938 ISO Abbreviation: Clin. Exp. Dermatol. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-12-07 Completed Date: 1992-12-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 13-5 Citation Subset: IM |
Affiliation:
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Electron Microscopy, Clinical Research Centre, Harrow, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiomyopathies
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pathology Female Humans Langerhans Cells / ultrastructure* Lentigo / pathology* Male Melanocytes / ultrastructure* Microscopy, Electron Syndrome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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