Document Detail

Accumulation of manganese and copper in pallidum of cirrhotic patients: role in the pathogenesis of hepatic encephalopathy?
MedLine Citation:
PMID:  8847998     Owner:  NLM     Status:  MEDLINE    
Concentrations of zinc, copper and manganese were measured by atomic absorption spectrometry in samples of globus pallidus obtained at autopsy from 9 patients with chronic liver disease and an equal number of age-matched controls. Manganese concentrations were significantly increased several fold (p < 0.01) in globus pallidus of liver disease patients accompanied by smaller but significant 2-fold increases of copper. Zinc concentrations, on the other hand, were within normal limits. Increased pallidal manganese offers a cogent explanation for the observed T1-weighted MRI signal hyperintensity in pallidum of cirrhotic patients. Increased copper content in brain suggests the existence of common pathophysiologic mechanisms in inherited (Wilson Disease) and acquired hepatocerebral disorders.
G P Layrargues; D Shapcott; L Spahr; R F Butterworth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolic brain disease     Volume:  10     ISSN:  0885-7490     ISO Abbreviation:  Metab Brain Dis     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  353-6     Citation Subset:  IM    
Liver Unit, Hôpital Saint-Luc (University of Montreal), Quebec.
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MeSH Terms
Copper / metabolism*
Globus Pallidus / metabolism*,  pathology
Hepatic Encephalopathy / metabolism*,  pathology
Manganese / metabolism*
Middle Aged
Spectrophotometry, Atomic
Reg. No./Substance:
7439-96-5/Manganese; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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