| Accumulation of galactonate in liver of suckling rats perfused with galactose. | |
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MedLine Citation:
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PMID: 6696759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Livers of 14-day-old suckling rats were perfused for 30 min in the nonrecirculating (once-through) mode with media containing 0-60 mM galactose. Galactonate was detected in livers perfused with as little as 1 mM galactose and increased with higher perfusate galactose to 178 nmoles per gram of liver at 60 mM hexose. Tissue galactonate levels were as high as 60% of galactose-1-phosphate which also accumulated under the same conditions. Galactonate was also found to be present in the effluent perfusate. The perfused suckling rat liver appears to be a physiological model for assessing the role of galactose oxidation to galactonate as an alternate metabolic pathway of galactose metabolism. |
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Authors:
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S Rogers; G Lichtenstein; D Gentile; S Segal |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 118 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-03-12 Completed Date: 1984-03-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 304-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Suckling / metabolism Galactose / metabolism* Galactosephosphates / isolation & purification Kinetics Liver / metabolism* Rats Rats, Inbred Strains Sugar Acids / isolation & purification, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HD 08536/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Galactosephosphates; 0/Sugar Acids; 13382-27-9/galactonic acid; 2255-14-3/galactose-1-phosphate; 26566-61-0/Galactose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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