Document Detail


Accumulation of ethoxyquin in the tissue.
MedLine Citation:
PMID:  2051496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethoxyquin (EQ) residue levels in the mouse tissue were determined by the HPLC-fluorometric detection method. Mice were given powdered feed containing 0, 0.125, and 0.5% EQ HCl and the EQ residue levels in liver, kidney, lung, and brain tissues were determined after 2, 4, 6, 10, and 14 wk (4 mice/group). The tissue samples were homogenized in 10 volumes (w/v) of acetonitrile-water (7:3, v/v), centrifuged, and the supernatants were stored in a freezer for 2-3 h or until the two layers separated; then the clear upper layers were analyzed. The mean EQ residue levels in the tissue ranged 0.84-4.58 micrograms EQ/g liver and 0.11-0.92 micrograms EQ/g brain. The relative weight of the liver (5.21-7.07% body weight) and the hepatic glutathione level (5.99-7.83 microM GSH/g tissue) of mice that received EQ were significantly higher than those of the controls (4.67-5.05% body weight and 4.30-5.78 microM GSH/g tissue, respectively). The mean hepatic mitochondrial glutathione level of the higher EQ feeding group, following dietary administration of EQ for 14 wk, was approximately twofold (1.68 nM GSH/mg protein) of both the control and the lower EQ feeding groups (0.83 and 0.74 nM GSH/mg protein, respectively).
Authors:
H L Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  33     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-24     Completed Date:  1991-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-36     Citation Subset:  IM    
Affiliation:
Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Carbon Radioisotopes / diagnostic use
Chromatography, High Pressure Liquid
Ethoxyquin / pharmacokinetics*,  pharmacology
Female
Liver / drug effects,  metabolism
Mice
Mice, Inbred ICR
Organ Size / drug effects
Tissue Distribution
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 91-53-2/Ethoxyquin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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