Document Detail

Accumulation and effects of nickel and thallium in early-life stages of fathead minnows (Pimephales promelas).
MedLine Citation:
PMID:  20116852     Owner:  NLM     Status:  MEDLINE    
Early-life stages of fathead minnows were exposed to environmentally relevant concentrations of aqueous and dietary nickel and thallium and metal accumulation was monitored from the embryo until the larvae reached 21 days after hatching. During and after metal exposure, 6 toxicity endpoints were measured: time to hatch, embryo survival rate, routine metabolic rate and the activity of key enzymes (lactate dehydrogenase, nucleoside diphosphate kinase (NDPK), cytochrome C oxidase (CCO)). Although both Ni and Tl bioaccumulation were significant in embryos and non-feeding larvae, water was the major source of Ni and Tl in feeding larvae. Exposure to aqueous Ni decreased time to hatch and increased aerobic and biosynthetic capacities (as indicated by a higher activity of CCO and NDPK, respectively), suggesting that aqueous Ni exposure stimulates metabolism in early-life stages of fathead minnows.
Dominique Lapointe; Patrice Couture
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-08
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  73     ISSN:  1090-2414     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  572-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Institut National de Recherche Scientifique-Centre Eau Terre Environnement, Université du Québec, 490 de Couronne, 490 rue de Couronne, Québec, QC, Canada G1K 9A9.
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MeSH Terms
Cyprinidae / growth & development*,  metabolism
Electron Transport Complex IV / analysis,  metabolism
Embryo, Nonmammalian / drug effects,  metabolism
L-Lactate Dehydrogenase / analysis,  metabolism
Nickel / analysis,  metabolism*,  toxicity
Nucleoside-Diphosphate Kinase / analysis,  metabolism
Thallium / analysis,  metabolism*,  toxicity
Water / analysis
Water Pollutants, Chemical / analysis,  metabolism*
Reg. No./Substance:
0/Water Pollutants, Chemical; 7440-02-0/Nickel; 7440-28-0/Thallium; 7732-18-5/Water; EC Dehydrogenase; EC Transport Complex IV; EC Kinase

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