Document Detail


Accumulation and depletion kinetics of erythromycin in rainbow trout (Oncorhynchus mykiss).
MedLine Citation:
PMID:  22436556     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Erythromycin is an antimicrobial agent recommended for the control and treatment of diseases caused by Gram-positive bacteria. Few studies, however, have determined the metabolic and pharmacokinetic aspects of this antimicrobial agent in fish. The aim of the present study, therefore, was to determine the accumulation and depletion time of erythromycin after administration of medicated feed containing 52mgkg(-1)bodyweightday(-1) for 8 days in rainbow trout (Oncorhynchus mykiss). Results were analyzed following the European Agency for Evaluation of Medicinal Products guidelines. We measured a withdrawal time of 187°C-day (°C-day=water temperature×days), lower than the value (500°C-day) recommended by Council Directive 2004/28/EC for veterinary medicinal products. Our results provide data to establish therapeutic regimens for the use of erythromycin in aquaculture.
Authors:
Daniel Vendrell; Lidia Serarols; José Luis Balcázar; Ignacio de Blas; Olivia Gironés; José Luis Múzquiz; Imanol Ruiz-Zarzuela
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-19
Journal Detail:
Title:  Preventive veterinary medicine     Volume:  -     ISSN:  1873-1716     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8217463     Medline TA:  Prev Vet Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Laboratory of Fish Pathology, Universidad de Zaragoza, c/Miguel Servet 177, 50013 Zaragoza, Spain.
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