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Accumulation of circulating advanced oxidation protein products is an independent risk factor for ischemic heart disease in maintenance hemodialysis patients.
MedLine Citation:
PMID:  22738256     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SUMMARY AT A GLANCE: These investigators examined the serum levels of advanced oxidation protein products (AOPPs) in patients on hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD) in a cross-section study and tested AOPPs as an independent risk factor for cardiovascular disease. The levels of AOPPs were significantly elevated in both HD and CAPD patients compared to healthy controls. However, accumulation of AOPPs was more significant in HD compared to CAPD patients. Only in HD patients, the AOPPs levels exhibit an association with ischemic heart disease. ABSTRACT: Aim:  Whether the burden of AOPPs accumulation, a marker of oxidative stress, is affected by dialysis modality remains unclear. We compared the serum levels of AOPPs in patients on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) and tested the hypothesis that an accumulation of AOPPs was an independent risk factor for cardiovascular disease. Methods:  This was a cross-section study. A total of 2,095 patients (1539 HD, 556 CAPD) were recruited from the 9 of the largest dialysis centers in China. Persons in medical centers for disease screening were selected as the control. Patients maintained on HD were dialyzed twice or thrice weekly. CAPD patients used lactate-buffered, glucose-containing solutions. The patients' data were abstracted from the medical record. The serum levels of AOPPs were determined by spectrophotometric detection. Results:  The levels of AOPPs were significantly elevated in both HD and CAPD patients compared to healthy controls. Accumulation of AOPPs was more significant in HD compared to CAPD population. Meanwhile, AOPPs accumulation was associated with the presence of ischemic heart disease (IHD) only in HD, but not CAPD patients. A higher proportion of IHD was found in HD population among those with higher levels of AOPPs in each category of age and irrespective of the presence or absence of high triglyceride. Multivariate regression analysis indicated that accumulation of AOPPs was an independent risk factor for IHD in HD population. Conclusion:  Accumulation of AOPPs was more significant in HD compared to CAPD patients. The level of AOPPs was independently associated with IHD only in HD patients. © 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.
Authors:
Qiugen Zhou1; Shengjie Wu1; Jianping Jiang; Jianwei Tian; Jianghua Chen; Xueqing Yu; Pingyan Chen; Changlin Mei; Fei Xiong; Wei Shi; Wei Zhou; Xusheng Liu; Shiren Sun; Di Xie; Jun Liu; Xin Xu; Min Liang; Fanfan Hou
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.
Affiliation:
Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Key Lab for Organ Failure Research, Ministry of Education; Guangzhou, China; Division of Nephrology, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China; Division of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Biostatistics, Southern Medical University, Guangzhou, China; Division of Nephrology, Changzheng Hospital, Secondary Military Medical University, Shanghai, China; Division of Nephrology, The First People's Hospital, Wuhan, China; Division of Nephrology, Guangdong General Hospital, Guangzhou, China; Division of Nephrology, The 309th Hospital of People's Liberation Army, Beijing, China; Division of Nephrology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China; Division of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
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