| Accumulation of atherogenic remnants and lipoprotein(a) in the nephrotic syndrome: relation to remission of proteinuria. | |
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MedLine Citation:
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PMID: 7768011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although lipoprotein abnormalities of the nephrotic syndrome are assumed to be related to the presence of proteinuria, this topic has not been investigated extensively. We measured lipoproteins from 19 nonuremic patients during and after remission of the nephrotic syndrome in an effort to determine the extent of their putative atherogenicity. As expected, disturbances involved primarily the apoprotein B-containing lipoproteins. No patient showed serum lipoprotein(a) [Lp(a)] < 300 mg/L during the acute phase. Lp(a) concentrations correlated significantly with those of apoprotein B, and both values decreased dramatically with the remission of the nephrotic syndrome. Surprisingly, despite the resolution of proteinuria, concentrations of intermediate-density lipoproteins and Lp(a) remained above normal in hypertriglyceridemic patients, suggesting a residual effect of nephrosis in the overall lipoprotein transport. Accumulation of atherogenic remnants should be considered a characteristic of the hyperlipidemia of the nephrotic syndrome, and aggressive treatment to reduce proteinuria is mandatory. |
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Authors:
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J Joven; J M Simó; E Vilella; J Camps; E Espinel; C Villabona |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical chemistry Volume: 41 ISSN: 0009-9147 ISO Abbreviation: Clin. Chem. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-07-06 Completed Date: 1995-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421549 Medline TA: Clin Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 908-13 Citation Subset: IM |
Affiliation:
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Hospital Universitari de Sant Joan, Reus, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Apolipoprotein A-I / blood Apolipoprotein A-II / blood Apolipoproteins B / blood Arteriosclerosis / etiology* Cholesterol / blood Female Humans Lipoprotein(a) / blood* Lipoproteins / blood* Male Middle Aged Nephrotic Syndrome / blood*, complications Proteinuria / blood Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoprotein A-II; 0/Apolipoproteins B; 0/Lipoprotein(a); 0/Lipoproteins; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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