Document Detail

Accumulation of alprenolol in some polypeptide hormone producing cells and in melanin-containing tissues.
MedLine Citation:
PMID:  1093347     Owner:  NLM     Status:  MEDLINE    
The distribution of the beta-adrenergic-receptor blocking drug alprenolol labelled with 3H was studied in mice by whole body autoradiography. The most characteristic feature in the distribution pattern was the accumulation in endocrine cells within the pancreatic islets, the adrnal medulla, the pituitary gland and some cells of the thyroid, presumably representing the parafollicular cells. A hgih accumulation was also observed in melanin-containing tissues.
P Slanina; H Tjälve
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  79     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-07-23     Completed Date:  1975-07-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  202-8     Citation Subset:  IM    
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MeSH Terms
Adrenal Medulla / metabolism*
Alprenolol / metabolism*
Gastric Juice / metabolism
Islets of Langerhans / metabolism*
Kidney / metabolism
Liver / metabolism
Lung / metabolism
Melanins / metabolism*
Mice, Inbred C57BL
Pituitary Gland / metabolism*
Thyroid Gland / metabolism*
Reg. No./Substance:
0/Melanins; 13655-52-2/Alprenolol

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