| Accumulation of D-aspartic acid with age in the human brain. | |
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MedLine Citation:
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PMID: 6857259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin. |
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Authors:
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E H Man; M E Sandhouse; J Burg; G H Fisher |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 220 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1983 Jun |
Date Detail:
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Created Date: 1983-07-08 Completed Date: 1983-07-08 Revised Date: 2007-03-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1407-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aging* Aspartic Acid / analysis*, physiology Brain Chemistry* Eye Proteins / analysis Humans Lens Nucleus, Crystalline / analysis Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Eye Proteins; 56-84-8/Aspartic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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