Document Detail


Accumulating evidence supports a taste component for free fatty acids in humans.
MedLine Citation:
PMID:  21557960     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The requisite criteria for what constitutes a taste primary have not been established. Recent advances in understanding of the mechanisms and functions of taste have prompted suggestions for an expanded list of unique taste sensations, including fat, or more specifically, free fatty acids (FFA). A set of criteria are proposed here and the data related to FFA are reviewed on each point. It is concluded that the data are moderate to strong that there are: A) adaptive advantages to FFA detection in the oral cavity; B) adequate concentrations of FFA to serve as taste stimuli; C) multiple complimentary putative FFA receptors on taste cells; D) signals generated by FFA that are conveyed by gustatory nerves; E) sensations generated by FFA that can be detected and scaled by psychophysical methods in humans when non-gustatory cues are masked; and F) physiological responses to oral fat/FFA exposure. On no point is there strong evidence challenging these observations. The reviewed findings are suggestive, albeit not definitive, that there is a taste component for FFA.
Authors:
Richard D Mattes
Publication Detail:
Type:  Journal Article; Review     Date:  2011-05-06
Journal Detail:
Title:  Physiology & behavior     Volume:  104     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-07-19     Completed Date:  2011-11-30     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  624-31     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Biological / physiology
Animals
Fatty Acids, Nonesterified / physiology*
Humans
Mouth / innervation,  physiology*
Signal Transduction / physiology
Taste / physiology*
Taste Buds / physiology
Taste Perception / physiology*
Grant Support
ID/Acronym/Agency:
R01 DK045294/DK/NIDDK NIH HHS; R01 DK045294-16/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified
Comments/Corrections

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