Document Detail

Accounting for flow dependence of respiratory resistance during exercise.
MedLine Citation:
PMID:  12809799     Owner:  NLM     Status:  MEDLINE    
Studies of airway function during exercise have produced conflicting results both in healthy and diseased subjects. Respiratory resistance (Rrs) was measured using an impulse oscillation technique. A flow/resistance curve was established for each of 16 healthy males during voluntary hyperventilation (VHV) at rest. Then, Rrs and flow were measured immediately (t(0)) and 90 sec (t(90)) after exercise on a cycle ergometer at 60, 70, and 80% of maximal aerobic power. The flow/resistance relationship at rest during VHV was used to assess the flow dependence of Rrs. Rrs at t(0) was higher than at rest (P <0.01) but lower than Rrs obtained at matched flow during VHV (P <0.05). In healthy subjects, the linear increase in Rrs with VHV indicates airflow dependency of Rrs following Rohrer's equation. The relative decrease in Rrs with exercise suggests bronchodilation. The bronchodilating effect disappeared promptly when exercise was stopped suggesting that it may have been related to a reflex mechanism.
Claire de Bisschop; Aurélien Pichon; Hervé Guénard; André Denjean
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  136     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-17     Completed Date:  2003-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  65-76     Citation Subset:  IM    
Laboratoire d'Analyse de la Performance Motrice Humaine, Faculté des Sciences du Sport, UPRES EA 2253, 4 allée Jean Monnet, 86000 Poitiers, France.
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MeSH Terms
Airway Resistance / drug effects,  physiology*
Chest Wall Oscillation / methods
Dose-Response Relationship, Drug
Exercise / physiology*
Hyperventilation / physiopathology
Maximal Expiratory Flow-Volume Curves
Methacholine Chloride / pharmacology
Muscarinic Agonists / pharmacology
Pulmonary Ventilation / drug effects,  physiology*
Rest / physiology
Time Factors
Reg. No./Substance:
0/Muscarinic Agonists; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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