Document Detail

Acclimation to hypoxia does not improve hypoxic survival of the immature pig in confined atmosphere.
MedLine Citation:
PMID:  18251342     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Humans may be accidentally trapped in a confined atmosphere in which oxygen availability is limited. If acclimation would extend survival, hypoxic acclimation in confined spaces would be recommended. METHODS: After hypoxic acclimation, an immature pig was transferred into an experimental sealed chamber. The O2, CO2, chamber temperature, and pressure changes due to the animal's breathing were recorded. Six days acclimation (n = 3) and 3 weeks of acclimation (n = 3) were compared to control pigs (n = 3). RESULTS: No signs of acute mountain sickness were noted in the pigs acclimated for 6 days, but some acute symptoms (which were resolved on the following day) were observed during the 3-week acclimation. The terminal partial pressure of inspired oxygen (PIO2; 3.5-3.6 kPa) was not affected by hypoxic acclimation. Oxygen consumption and CO2 production were similar in the three experimental groups. CONCLUSIONS: Our hypothesis that hypoxia acclimation would produce improved survival in a confined space was not supported by the results. It is possible that at very low inspired oxygen of 3.6 kPa, the oxygen consumption of critical life-supporting tissue reached the limit of viable cells in mammals. If this is right, no further improvement could be expected after hypoxic acclimation.
Ran Arieli; Alon Vitenstein; Eyal Peled
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Military medicine     Volume:  173     ISSN:  0026-4075     ISO Abbreviation:  Mil Med     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-02-06     Completed Date:  2008-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984771R     Medline TA:  Mil Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
Israel Naval Medical Institute, IDF Medical Corps, PO Box 8040, 31 080 Haifa, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Anoxia / mortality*,  physiopathology
Carbon Dioxide / metabolism
Oxygen / metabolism
Oxygen Consumption
Partial Pressure
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The use of a dermal regeneration template following excision of a giant melanocytic nevus in a poten...
Next Document:  How are drugs approved? Part 1: the evolution of the Food and Drug Administration.