Document Detail

Accidental use of low-dose 5-fluorouracil in pregnancy.
MedLine Citation:
PMID:  1667807     Owner:  NLM     Status:  MEDLINE    
Five percent 5-fluorouracil (5-FU), an antineoplastic agent, is often applied to the lower genital tract in the treatment of vaginal and vulvar human papillomavirus infections. Little is known regarding possible teratogenic effects from its topical use in pregnancy. Five cases of antenatal lower genital tract 5-FU use were correlated with pregnancy outcome. Topical 5-FU was applied up to 16 weeks' gestation. Intravaginal doses ranged from 1 to 2.5 g; one patient applied 5-FU to the vulva. Antenatal ultrasound performed on four patients did not show any fetal structural abnormalities. One patient underwent antenatal genetic amniocentesis that detected a 47,XXX complement of chromosomes. All the pregnancies continued without complications and with subsequent term delivery of healthy infants. The unwitting vaginal and vulvar use of 5-FU in pregnancy did not result in significant morbidity or mortality; expectant management of such pregnancies should be considered.
L Van Le; D J Pizzuti; M Greenberg; R Reid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  36     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-06-26     Completed Date:  1992-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  872-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of North Carolina Hospitals, Chapel Hill 27599.
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MeSH Terms
Abnormalities, Drug-Induced / diagnosis,  epidemiology
Administration, Intravaginal
Fluorouracil / administration & dosage,  adverse effects*
Genital Diseases, Female / drug therapy*
Gestational Age
Hospitals, University
Michigan / epidemiology
Pregnancy Complications, Infectious / drug therapy*
Pregnancy Outcome*
Prenatal Diagnosis
Tumor Virus Infections / drug therapy*
Wisconsin / epidemiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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