Document Detail


Accidental use of low-dose 5-fluorouracil in pregnancy.
MedLine Citation:
PMID:  1667807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five percent 5-fluorouracil (5-FU), an antineoplastic agent, is often applied to the lower genital tract in the treatment of vaginal and vulvar human papillomavirus infections. Little is known regarding possible teratogenic effects from its topical use in pregnancy. Five cases of antenatal lower genital tract 5-FU use were correlated with pregnancy outcome. Topical 5-FU was applied up to 16 weeks' gestation. Intravaginal doses ranged from 1 to 2.5 g; one patient applied 5-FU to the vulva. Antenatal ultrasound performed on four patients did not show any fetal structural abnormalities. One patient underwent antenatal genetic amniocentesis that detected a 47,XXX complement of chromosomes. All the pregnancies continued without complications and with subsequent term delivery of healthy infants. The unwitting vaginal and vulvar use of 5-FU in pregnancy did not result in significant morbidity or mortality; expectant management of such pregnancies should be considered.
Authors:
L Van Le; D J Pizzuti; M Greenberg; R Reid
Related Documents :
2673337 - Effect of external cephalic version in late pregnancy on presentation at delivery: a ra...
9481567 - Efficacy of external cephalic version performed at term.
8304037 - Outcome of pregnancy and childbirth following laryngectomy.
17120177 - Correlation of pelvic organ prolapse quantification system scores with obstetric parame...
7091227 - Fluoride tablet supplementation during pregnancy for caries immunity: a study of the of...
9159457 - Pregnancy after transfer of embryos which were generated from in-vitro matured oocytes.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  36     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-06-26     Completed Date:  1992-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  872-4     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of North Carolina Hospitals, Chapel Hill 27599.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / diagnosis,  epidemiology
Administration, Intravaginal
Adolescent
Adult
Female
Fluorouracil / administration & dosage,  adverse effects*
Genital Diseases, Female / drug therapy*
Gestational Age
Hospitals, University
Humans
Michigan / epidemiology
Papillomaviridae*
Pregnancy
Pregnancy Complications, Infectious / drug therapy*
Pregnancy Outcome*
Prenatal Diagnosis
Tumor Virus Infections / drug therapy*
Wisconsin / epidemiology
Chemical
Reg. No./Substance:
51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of conduction block at axon bifurcations on synaptic transmission to different postsynaptic n...
Next Document:  Immunomodulation of human cytomegalovirus infection on interferon system in patients with systemic l...