Document Detail

Accidental intraventricular vincristine administration: an avoidable iatrogenic death.
MedLine Citation:
PMID:  8918096     Owner:  NLM     Status:  MEDLINE    
A patient with acute lymphoblastic leukaemia was mistakenly given vincristine intraventricularly, as part of an intensified course of chemotherapy. Despite a CNS washout and supportive treatment, the patient developed progressive ascending paralysis, gradually lapsed into coma and died some 10 days later. Autopsy and post-mortem histological examination showed evidence of brain death caused by florid encephalomyelitis, apparently induced by the intraventricular administration of vincristine.
G Lau
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medicine, science, and the law     Volume:  36     ISSN:  0025-8024     ISO Abbreviation:  Med Sci Law     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-01-02     Completed Date:  1997-01-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400721     Medline TA:  Med Sci Law     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  263-5     Citation Subset:  IM    
Department of Forensic Medicine, Institute of Science and Forensic Medicine, Singapore, Republic of Singapore.
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MeSH Terms
Antineoplastic Agents, Phytogenic / administration & dosage,  poisoning*
Fatal Outcome
Injections, Intraventricular / adverse effects
Leukemia, Lymphoid / drug therapy*
Medication Errors*
Vincristine / administration & dosage,  poisoning*
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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