| Accidental human injection of Excenel RTU: ceftiofur hydrochloride in cottonseed oil. | |
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MedLine Citation:
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PMID: 18608258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: There is little knowledge within the medical community of the existence of veterinary antibiotics in oil-based suspensions and the adverse effects that may occur with accidental human injection. CASE REPORT: A farmer injected an unknown quantity of Excenel RTU into her right thigh. Despite early debridement she developed a deep infection and recurrent chronic inflammation in the subcutaneous tissues and muscle secondary to the cottonseed oil suspension. Radical debridement and extensive split skin grafting was required but she still has had recurrences 12 months after injury. DISCUSSION: Prompt surgical debridement should be performed as in cases of oil based veterinary vaccines. Despite being an antibiotic there is a significant risk of infection from a dirty needle following inoculation and multiple cultures should be taken and appropriate broad spectrum antibiotics used. Radical debridement and skin grafting necessitating specialist plastic surgical attention may be required. |
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Authors:
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David Gwynne-Jones; Patrick Lyall; Noelyn A Hung; Grant Meikle |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical toxicology (Philadelphia, Pa.) Volume: 46 ISSN: 1556-9519 ISO Abbreviation: Clin Toxicol (Phila) Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-12 Completed Date: 2008-12-01 Revised Date: 2009-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101241654 Medline TA: Clin Toxicol (Phila) Country: United States |
Other Details:
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Languages: eng Pagination: 908-10 Citation Subset: AIM; IM |
Affiliation:
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Dunedin Hospital, Orthopaedics, and Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. david.gwynne-jones@stonebow.otago.ac.nz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animal Husbandry Cephalosporins / adverse effects* Cottonseed Oil / adverse effects* Debridement / methods Female Humans Infection / etiology Inflammation / chemically induced Needlestick Injuries / complications* Occupational Diseases / etiology Recurrence Skin Transplantation / methods Veterinary Medicine |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins; 0/Cottonseed Oil; 80370-57-6/ceftiofur |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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