Document Detail


Accidental dextromethorphan ingestions in children less than 5 years old.
MedLine Citation:
PMID:  19031376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The purpose of this study is to evaluate the clinical presentation of accidental dextromethorphan (DXM) ingestions in children <5 years old. Two consecutive years of poison center patient encounters were reviewed. Data including age, outcomes, amount of DXM ingested, co-ingestions, vital signs, clinical manifestations, hospital admissions, and mortality were abstracted. Data were analyzed using descriptive statistics.
DISCUSSION: A total of 304 cases were identified with a mean age of 28.2 months (72% were > or =23 months). All cases co-ingested other products of over-the-counter cough and cold medications (i.e., acetaminophen, pseudoephedrine, guaifenesin, ibuprofen, various H1 receptor antagonists, and very infrequently ethanol). The mean DXM dose ingested was 35.0 mg (2.64 mg/kg). Of the patients, 62 (20.4%) experienced lethargy as the sole neurological sign and no patient had any cardiovascular abnormalities. Only 1 (13-monthold) patient, who ingested 3.2 mg/kg and presented with lethargy, was hospitalized and subsequently discharged 14 hours later. No deaths were recorded.
CONCLUSION: As demonstrated in our patient population, accidental ingestions of DXM in the pediatric patient did well with supportive care alone and rarely required inpatient treatment.
Authors:
Frank LoVecchio; Anthony Pizon; Leslie Matesick; Sean O'Patry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical toxicology : official journal of the American College of Medical Toxicology     Volume:  4     ISSN:  1556-9039     ISO Abbreviation:  J Med Toxicol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-02-24     Revised Date:  2013-08-01    
Medline Journal Info:
Nlm Unique ID:  101284598     Medline TA:  J Med Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-3     Citation Subset:  IM    
Affiliation:
Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA. Frank.LoVecchio@bannerhealth.com
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MeSH Terms
Descriptor/Qualifier:
Accidents, Home*
Antitussive Agents / poisoning*
Child, Preschool
Dextromethorphan / poisoning*
Eating
Follow-Up Studies
Humans
Infant
Poison Control Centers / statistics & numerical data
Reproducibility of Results
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antitussive Agents; 125-71-3/Dextromethorphan
Comments/Corrections

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