| Accidental acute clidinium toxicity. | |
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MedLine Citation:
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PMID: 19465630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clidinium bromide (N-methyl-quinuclidinyl-benzylate) is a rarely used antimuscarinic drug that is marketed in combination with chlordiazepoxide as an antispasmodic for use in irritable bowel syndrome. A case is reported of an accidental staggered overdose of clidinium bromide 50 mg in a patient using illicit chlordiazepoxide. The presenting features were mildly dilated pupils and palpitation secondary to sinus tachycardia that persisted for 11 h after the time of first ingestion. Emergency physicians should be aware of the potential for antimuscarinic toxicity in patients using illicit chlordiazepoxide. |
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Authors:
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S E Richardson; K Edwards |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Emergency medicine journal : EMJ Volume: 26 ISSN: 1472-0213 ISO Abbreviation: Emerg Med J Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100963089 Medline TA: Emerg Med J Country: England |
Other Details:
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Languages: eng Pagination: 460 Citation Subset: IM |
Affiliation:
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Emergency Department, John Radcliffe Hospital, Headley Way, Oxford, UK. serichardson@doctors.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Chlordiazepoxide / poisoning* Humans Male Mydriasis / chemically induced Parasympatholytics / poisoning* Quinuclidinyl Benzilate / analogs & derivatives*, poisoning Street Drugs / poisoning* Tachycardia, Sinus / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Parasympatholytics; 0/Street Drugs; 58-25-3/Chlordiazepoxide; 6581-06-2/Quinuclidinyl Benzilate; 7020-55-5/clidinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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