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Accidental PUVA burns, vitiligo and atopic diathesis resulting in prurigo nodularis: a logical but undocumented rarity.
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MedLine Citation:
PMID:  23197209     Owner:  NLM     Status:  In-Data-Review    
Vitiligo is a dreaded disease in India due to its social and cultural consequences. PUVA and PUVAsol are the main treatment modalities for vitiligo vulgaris. To the best of our knowledge, this is the first case of accidental PUVA burns eventuating in prurigo nodularis lesions to be reported in a female patient who was undergoing home PUVA therapy. The itch is so prominent and disabling that the focus of the patient has shifted from treating her vitiligo to ameliorating the pruritus.
Shyam Bhanushankar Verma; Uwe Wollina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anais brasileiros de dermatologia     Volume:  87     ISSN:  1806-4841     ISO Abbreviation:  An Bras Dermatol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0067662     Medline TA:  An Bras Dermatol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  891-3     Citation Subset:  IM    
Nirvana Skin Clinic, Vadodara, India.
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Journal Information
Journal ID (nlm-ta): An Bras Dermatol
Journal ID (iso-abbrev): An Bras Dermatol
Journal ID (publisher-id): An. bras. dermatol.
ISSN: 0365-0596
ISSN: 1806-4841
Publisher: Sociedade Brasileira de Dermatologia
Article Information
Download PDF©2012 by Anais Brasileiros de Dermatologia
Received Day: 29 Month: 11 Year: 2011
Accepted Day: 15 Month: 3 Year: 2012
Print publication date: Season: Nov-Dec Year: 2012
Volume: 87 Issue: 6
First Page: 891 Last Page: 893
PubMed Id: 23197209
ID: 3699928
DOI: 10.1590/S0365-05962012000600011

Accidental PUVA burns, vitiligo and atopic diathesis resulting in prurigo nodularis: a logical but undocumented rarity*
Shyam Bhanushankar Verma1
Uwe Wollina2
1MBBS, DV&D, FRCP (Lon.) - Consultant dermatologist, Nirvana Skin Clinic - Vadodara, India
2MD - Academic Teaching Hospital Dresden-Friedrichstadt, Department of Dermatology and Allergology - Dresden, German
Correspondence: Mailing address: Shyam Bhanushankar Verma, 18 AmeeSociety - Diwalipura, Vadodara 390 015, INDIA, Phone: +91 265 232 3838, E-mail:


Vitiligo is a dreaded disease in India due to its disfiguring nature and stigmatization. We describe a woman who had accidental burns during home treatment with PUVA. She had an underlying atopic diathesis. The burns healed leaving severe prurigo nodularis, which caused crippling pruritus. To the best of our knowledge, this is the first time prurigo nodularis has been reported in the dermatologic literature as a complication of accidental PUVA burns in a vitiligo patient.


A 50-year-old woman presented to this clinic with severely pruritic nodules and plaques on her legs and breasts. She developed vitiligo at the age of 18 years and had been unsuccessfully treated with many drugs. In 1991, she was treated with home psoralen plus ultraviolet-A radiation (PUVA), using 20 mg of oral methoxsalen. The light source used was a set of 4 tube lights of 100W, emitting UVA with wavelengths between 315 and 350 nm, and she exposed the affected areas for three minutes three times a week. Within about 5 months, there was marked improvement of the vitiligo lesions on her legs and also total clearing of the lesions on her face, except for the ones on the lips. Around this time, she accidentally fell asleep during her PUVA sessions and woke up 60 minutes later with blistering burns on her breasts and legs, which took a month to heal. During the healing stage, she started developing thickened skin, nodules and plaques on her legs and breasts, which were intensely itchy. She was given emollients, topical steroids, antihistamines, individually and in combination, with little benefit. Many nodules coalesced to form scaly plaques. Then, her homeopath husband started treating her with some homeopathic medication, which apparently caused resolution of the lesions for many years. The lesions only reappeared in 2004. Several physicians and dermatologists diagnosed her condition as psoriasis and post-burn keloids. She was prescribed oral steroids by a private practitioner for a few months, which was later stopped as she developed diabetes. She now has excruciating itching, which has severely affected her quality of life.

On examination, she had vitiligo on her breasts and lower limbs, showing perifollicular pigmentation. Her legs were studded with thick, horny, hyperkeratotic nodules with a rough surface, many of them coalescing to form plaques on the anterior aspect (Figure 1). She had severely pruritic erythematous nodules on the breasts (Figure 2). The skin on her face, abdomen, back and upper limbs was normal. She was diabetic, hypothyroid and took metformin and thyroxine daily. Her blood work up and serum chemistry were normal, except for an IgE level of 700 IU/ml, with no history, signs or symptoms of atopy such as chronic itching, eczema, allergic rhinitis or asthma. She, however, had a family history of eczema and allergic rhinitis. A skin biopsy taken from the nodule showed a superficial perivascular lymphocytic infiltrate with moderate irregular epidermal hyperplasia. The papillary dermis was thickened with papillomatosis and showed thickened bundles of collagen in a vertical array. The capillaries in the papillary dermis were increased in number and thick-walled. The granular layer was thickened and the stratum corneum showed marked compact orthokeratosis (Figure 3). One of the sections showed abundant deposit of amyloid in the papillary dermis. The histological diagnosis was prurigo nodularis (PN) associated with lichen amyloidosis (Figure 3). We started her on 900 mg of gabapentin with topical halobetasol and petrolatum, and she reported a relief of about 20% of her itching in 30 days.


We report a case of prurigo nodularis occurring on the sites of PUVA burns in a vitiligo patient. Oral PUVA, which is one of the most common treatment modalities for India's millions of vitiligo patients, has side effects that may be short-term or long-term. Short-term adverse effects include erythema, swelling, dry skin, pruritus, axillary freckling, increased recurrence of herpes simplex virus and, rarely, phototoxic blisters. Possible long-term adverse effects are accelerated skin ageing with wrinkle formation, telangectasias, lentigines, elastosis, xerosis and pigmentary changes.1 High cumulative PUVA exposure is associated with a dose-related increase in the risk of nonmelanoma skin cancer, particularly genital and cutaneous squamous cell carcinoma, in Caucasians only.2 However, nodular prurigo has never been reported.

Accidental burns during photochemotherapy have been reported too, including burns during self-treatment, as seen in this patient.3,4 Bothersome pruritus following burns per se is a known phenomenon, though there is a paucity of long-term prospective studies documenting the course and magnitude of this phenomenon.5,6 Burns are known inducers of neuropathic itch. A study by Van Loey et al. documented itching at 3, 12 and 24 months after burns and recorded mild to severe itching in 87%, 70% and 67% of patients.6 However, this appears to be the first case of prurigo nodularis developing after accidental PUVA burns. We propose the following logical sequence. Vitiliginous skin is more prone to burns. The accidental PUVA burns due to gross overdose initiated the itch in this patient, who also had atopic diathesis, indicated by a high level of serum IgE, and a family history of eczema and allergic rhinitis. Itching is known to induce hyperplastic cutaneous response, and this probably would have lead to the development of prurigo nodularis (PN) in this patient. There is a report of a bomb blast injury causing prurigo nodularis-like lesions.7 The diagnosis of prurigo nodularis is based upon family and personal history, typical clinical presentation and distribution of the lesions along the cleavage lines (Langer's lines) of the skin and is confirmed by histopathology. The amyloid deposit seen in some sections could be due to the chronic scratching in PN.

Highly characteristic of PN is the presence of thick compact orthohyperkeratosis; the hairy palm sign (folliculosebaceous units in nonvolar skin in conjunction with a thick and compact cornified layer, like that of volar skin); irregular epidermal hyperplasia or pseudoepitheliomatous hyperplasia; focal parakeratosis; hypergranulosis; fibrosis of the papillary dermis with vertically arranged collagen fibers; increased number of fibroblasts and capillaries; a superficial, perivascular and/or interstitial inflammatory infiltrate of lymphocytes, macrophages and, to a lesser extent, eosinophils and neutrophils.8 Histological analysis of lesional and nonlesional skin in PN has demonstrated reduced density of nerve endings, findings suggesting a cutaneous neuropathy.9 Interestingly, the itch induced by burns, which would have played a major role in the development of PN, is also neuropathic in origin.5 The rationale of using gabapentin is that it has been tried with varying success in both burn-induced itching and PN. 5,10,11

We believe we are reporting the first case of accidental PUVA burns developing prurigo nodularis in a woman with atopic diathesis in the dermatologic literature.


Conflict of interest: None

Financial funding: None

fn01* Work conducted at Nirvana Skin Clinic - Vadodara, India.

1. Abdel Naser MB,Wollina U,El Okby M,El Shiemy S. Psoralen plus ultraviolet A irradiation-induced lentigines arising in vitiligo: Involvement of vitiliginous and normal appearing skinClinExpDermatolYear: 200429380382
2. Murase JE,Lee EE,Koo J. Effect of ethnicity on the risk of developing nonmelanoma skin cancer following long-term PUVA therapyInt J DermatolYear: 2005441016102116409267
3. Herr H,Cho HJ,Yu S. Burns caused by accidental overdose of photochemotherapy (PUVA)BurnsYear: 20073337237517218059
4. Sulliman MT,Abdolmoneim M. Severe burns following phototherapy with PUVA for vitiligo: A preventable complication that is still happeningBurnsYear: 200531106316288964
5. Goutos I,Dziewulski P,Richardson PM. Pruritus in burns: Review articleJ Burn Care ResYear: 20093022122819165110
6. Van Loey NE,Bremer MK,Faber AW,Middelkoop E,Nieuwenhuis MK. Itching following burns: Epidemiology and predictorsBr J DermatolYear: 20081589510017986307
7. Ghosh SK,Bandyopadhyay D,Ghosh A,Sarkar S,Mandal RK. Prurigonodularis-like skin eruptions after bomb-blast injuryClinExpDermatolYear: 200934
8. Weigelt N,Metze D,Ständer S. Prurigonodularis: Systematic analysis of 58 histological criteria in 136 patientsJ Cutan PatholYear: 20103757858620002240
9. Schuhknecht B,Marziniak M,Wissel A,Phan NQ,Pappai D,Dangelmaier J,et al. Reduced intraepidermal nerve fibre density in lesional and nonlesional prurigonodularis skin as a potential sign of subclinical cutaneous neuropathyBr J DermatolYear: 2011165859121410670
10. Gencoglan G,Inanir I,Gunduz K. Therapeutic hotline. Treatment of prurigonodularis and lichen simplex chronicus with gabapentinDermatolTherYear: 201023194198
11. Ahuja RB,Gupta R,Gupta G,Shrivastava P. A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritusBurnsYear: 20113720320721075537


[Figure ID: f01]

Multiple coalescing erythematous excoriated nodules on both legs

[Figure ID: f02]

Erythematous nodules on vitiliginous skin on her breast

[Figure ID: f03]

Massive hyperorthokeratosis associated with hypergranulosis and acanthotic epidermis with saw-tooth-like proliferations. Focal basal cell degeneration and a mild lymphocytic inflammatory infiltrate in the dermis. (H&E 40X)

Article Categories:
  • Case Report

Keywords: PUVA Therapy, Prurigo, Pruritus, Vitiligo.

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