Document Detail

Accessory atrioventricular myocardial pathways in mouse heart development: substrate for supraventricular tachycardias.
MedLine Citation:
PMID:  21399557     Owner:  NLM     Status:  MEDLINE    
Atrioventricular reentry tachycardia (AVRT) requiring an accessory atrioventricular pathway (AP) is the most common type of arrhythmia in the perinatal period. The etiology of these arrhythmias is not fully understood as well as their capability to dissipate spontaneously in the first year of life. Temporary presence of APs during annulus fibrosus development might cause this specific type of arrhythmias. To study the presence of APs, electrophysiological recordings of ventricular activation patterns and immunohistochemical analyses with antibodies specifically against atrial myosin light chain 2 (MLC-2a), Periostin, Nkx2.5, and Connexin-43 were performed in embryonic mouse hearts ranging from 11.5 to 18.5 days post-conception (dpc). The electrophysiological recordings revealed the presence of functional APs in early (13.5-15.5 dpc) and late (16.5-18.5 dpc) postseptated stages of mouse heart development. These APs stained positive for MLC-2a and Nkx2.5 and negative for Periostin and Connexin-43. Longitudinal analyses showed that APs gradually decreased in number (p = 0.003) and size (p = 0.035) at subsequent developmental stages (13.5-18.5 dpc). Expression of periostin was observed in the developing annulus fibrosus, adjacent to APs and other locations where formation of fibrous tissue is essential. We conclude that functional APs are present during normal mouse heart development. These APs can serve as transient substrate for AVRTs in the perinatal period of development.
Nathan D Hahurij; Denise P Kolditz; Regina Bökenkamp; Roger R Markwald; Martin J Schalij; Robert E Poelmann; Adriana C Gittenberger-De Groot; Nico A Blom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  70     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-09     Completed Date:  2011-10-07     Revised Date:  2012-05-25    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-43     Citation Subset:  IM    
Department of Pediatric Cardiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
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MeSH Terms
Accessory Atrioventricular Bundle / embryology,  metabolism,  physiopathology*
Action Potentials
Atrioventricular Node / embryology,  metabolism,  physiopathology*
Cell Adhesion Molecules / metabolism
Connexin 43 / metabolism
Gestational Age
Heart Rate
Homeodomain Proteins / metabolism
Mice, Inbred C57BL
Myosin Light Chains / metabolism
Tachycardia, Atrioventricular Nodal Reentry / embryology,  metabolism,  physiopathology*
Transcription Factors / metabolism
Grant Support
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Connexin 43; 0/GJA1 protein, mouse; 0/Homeodomain Proteins; 0/Mlc2a protein, mouse; 0/Myosin Light Chains; 0/Nkx2-5 protein, mouse; 0/Postn protein, mouse; 0/Transcription Factors

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