| Accessible pool and system parameters: assumptions and models. | |
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MedLine Citation:
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PMID: 1865556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Quantitative assessment of substrate metabolism from in vivo tracer kinetic data requires a model of the system, i.e., a hypothesis on the structure and functioning of the system. Some fundamentals of modeling important for studying intermediary metabolism in the steady state will be discussed. Accessible pool and system parameters are defined. Although the calculation of accessible pool parameters is structure-free, that of system parameters requires the use of non-compartmental or compartmental structures. Assumptions, bases for choice, and relative merits of these two modeling strategies are discussed. Glucose and leucine metabolism serve as prototypes to illustrate the theoretical points. |
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Authors:
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C Cobelli; M P Saccomani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 15 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 1991 May-Jun |
Date Detail:
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Created Date: 1991-09-11 Completed Date: 1991-09-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 45S-50S Citation Subset: IM |
Affiliation:
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Department of Electronics and Informatics, University of Padova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Glucose
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metabolism Kinetics Leucine / metabolism Mathematics Models, Biological* Nutritional Physiological Phenomena* |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose; 61-90-5/Leucine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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