Document Detail

Access to resorcylic acid lactones via phosphonate based intramolecular olefination.
MedLine Citation:
PMID:  20939525     Owner:  NLM     Status:  In-Process    
An approach to resorcylic acid lactones is described, exploiting an intramolecular olefination reaction for the generation of the 14-membered macrolactone. The synthetic route gave zearalenone precursors, and the preparations of other RAL analogues, trans- and cis-resorcylides are included, the latter being prepared by photoisomerization of the trans-isomer. β-Haloketone derivatives were also prepared in a highly stereoselective manner by conjugate addition of chloride or bromide to the E-enone using boron trichloride and boron tribromide, respectively.
Carmela Napolitano; Patrick McArdle; Paul V Murphy
Related Documents :
17479225 - Biotransformation of heterocyclic dinitriles by rhodococcus erythropolis and fungal nit...
22055095 - Closing the carbon balance for fermentation by clostridium thermocellum (atcc 27405).
994145 - A practical synthesis of codeine from dihydrothebainone.
19827755 - An efficient synthetic approach to polycyclic 2,5-dihydropyrroles from alpha-silyloxy k...
16808485 - Enhancement of amino acid detection and quantification by electrospray ionization mass ...
11045465 - Insight into acid-mediated asymmetric spirocyclization in the presence of a chiral diol.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  75     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7404-7     Citation Subset:  IM    
School of Chemistry, National University of Ireland, Galway, University Road, Galway, Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Synthesis, characterization, and in vitro pH-controllable drug release from mesoporous silica sphere...
Next Document:  Surface-bound cytomimetic assembly based on chemoselective and biocompatible immobilization and furt...