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An Access to Aza-Freidinger Lactams and E-Locked Analogs.
MedLine Citation:
PMID:  23320486     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Freidinger lactams, possessing a peptide bond configuration locked to Z, are important key elements of conformationally restricted peptidomimetics. In the present work, the C(α)H(i+1) unit has been replaced by N, leading to novel aza-Freidinger lactams. A synthesis to corresponding building blocks and their E-locked analogs is introduced. The versatile buildings blocks reported here are expected to serve as useful elements in peptide synthesis.
Authors:
Philipp A Ottersbach; Janina Schmitz; Gregor Schnakenburg; Michael Gütschow
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn , An der Immenburg 4, 53121 Bonn, Germany, and Institute of Inorganic Chemistry, University of Bonn , Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.
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