Document Detail

Access-site complications after rescue percutaneous coronary intervention during thrombolysis for acute myocardial infarction.
MedLine Citation:
PMID:  15668826     Owner:  NLM     Status:  MEDLINE    
Aggressive antithrombotic medical therapy may increase the rate of access-site complications after percutaneous coronary intervention. Frequently, emergency coronary interventions have to be performed in a situation when thrombolysis therapy was administered as the first-line therapeutic approach in acute myocardial infarction but failed to achieve stable conditions. We analyzed the rate of femoral bleeding complications after emergency coronary intervention in 76 consecutive patients with unsuccessful thrombolysis in acute myocardial infarction. All invasive procedures were performed in a time period no longer than eight hours after thrombolysis was administered. Additional antithrombotic therapy with heparin and glycoprotein IIb/IIIa-inhibitors was given during intervention in 100% and 38.2% of patients, respectively. In three patients (3.9%) femoral hematomas without therapeutic consequences were documented; one patient (1.3%) developed a hematoma requiring blood transfusion. A pseudoaneurysm, fistula or surgical vascular intervention did not occur. Coronary interventional procedures in rescue situations can be performed with excellent safety with respect to access-site bleeding complications even under conditions of ongoing thrombolysis therapy and aggressive antithrombotic medical regimens.
A Germing; M Lindstaedt; S Ulrich; W Bojara; T Lawo; A Mügge; P Grewe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für Kardiologie     Volume:  94     ISSN:  0300-5860     ISO Abbreviation:  Z Kardiol     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-25     Completed Date:  2005-05-31     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0360430     Medline TA:  Z Kardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  IM    
Medizinische Klinik II, Kardiologie und Angiologie, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany.
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MeSH Terms
Aged, 80 and over
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Angiography*
Drug Therapy, Combination
Femoral Artery*
Fibrinolytic Agents / adverse effects*,  therapeutic use
Hematoma / chemically induced
Heparin / adverse effects,  therapeutic use
Middle Aged
Myocardial Infarction / radiography,  therapy*
Platelet Glycoprotein GPIIb-IIIa Complex / adverse effects,  therapeutic use
Postoperative Hemorrhage / chemically induced*
Risk Factors
Thrombolytic Therapy*
Treatment Failure
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 9005-49-6/Heparin

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