Document Detail

Acceptance rate of clinical study endpoints and adequacy of source documentation: experience from clinical study endpoint review in NEAT001/ANRS143.
MedLine Citation:
PMID:  25394079     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: NEAT001/ANRS143 was an open-label, randomized, non-inferiority study comparing raltegravir+darunavir/r(RGV+DRV/r) vs. tenofovir/emtricitabine+darunavir/r (TDF/FTC+DRV/r) in HIV-infected antiretroviral naïve adults. Primary efficacy outcome was a composite of virological and clinical events by week 96.
MATERIALS AND METHODS: Clinical trial units collected and translated supporting documentation (SD) related to the investigator-reported events. A coordinator checked events and SD for consistency and completeness. The Endpoint Review Committee (ERC) determined if clinical events met pre-defined diagnostic criteria in categories "confirmed" or "probable". The ERC of 12 experienced, independent clinicians served in groups of three conducting individual reviews in writing, blinded to treatment arm. Differences of opinion were adjudicated in a second review by direct dialogue between reviewers. "Confirmed" events required adequate SD like laboratory, radiographic or pathology diagnostic reports. "Probable" events were typically based on clinical criteria.
RESULTS: Of the 164 serious and 3,964 adverse events reported in the study, 133 qualified for endpoint review, for a total of 153 adjudications:
CONCLUSIONS: Blinded endpoint review prevented unacceptably high false positive event rates documenting that real-time ascertainment of clinical endpoints is crucial for appropriateness of the overall results. Non-confirmed events jeopardize the statistical power in this and probably all kinds of clinical studies. The rejection rate was not indicative of poor study conduct - on the contrary over-reporting prevented missing events, which would have adversely impacted the trial. Adequacy of SD and investigator training on possible differences in event criteria in daily pragmatic clinical management compared to protocol defined criteria is essential.
Juan Berenguer; Ferdinand Wit; Per O Jansson; Christine Schwimmer; Justyna D Kowalska; Juliette Saillard; Alpha Diallo; Anton L Pozniak; François Raffi; Jesper Grarup
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Publication Detail:
Type:  Journal Article     Date:  2014-11-02
Journal Detail:
Title:  Journal of the International AIDS Society     Volume:  17     ISSN:  1758-2652     ISO Abbreviation:  J Int AIDS Soc     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101478566     Medline TA:  J Int AIDS Soc     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  19572     Citation Subset:  IM; X    
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