Document Detail

Accentuated cortico-cortical evoked potentials in neocortical epilepsy in areas of ictal onset.
MedLine Citation:
PMID:  20952353     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To determine whether patients with neocortical epilepsy show evidence for increased excitability measured by cortico-cortical evoked potentials (CCEPs) in ictal-onset regions.
METHODS: In patients undergoing intracranial recordings with subdural electrodes for epilepsy surgery, we measured amplitudes, latencies, and stimulus thresholds of CCEPs near ictal onset zones (iCCEPs), and compared with adjacent neocortex not associated with ictal EEG (nCCEP). CCEP amplitude and latency measurements were made with each stimulation site, using graded stimulation intensities.
RESULTS: Ten patients were included in this study. CCEPs were recorded in eight of 10 patients. The first negative (N1) iCCEP amplitude was higher than that of nCCEP in seven of the eight patients. In the group analysis, this difference was statistically significant. In three of these patients, the difference was individually significant. In one patient, the amplitude was higher in nCCEP than iCCEP and the area selected as nCCEP was within primary eloquent cortex. There was no significant difference seen in latency changes or stimulus threshold.
CONCLUSIONS: Accentuated CCEP amplitudes near ictal onset zones could reflect an increased excitability of the cortex associated with the epileptogenic zone in some patients with neocortical epilepsy. The response of the neocortex to low-frequency stimulation may vary depending on the presence or absence of intrinsic epileptogenicity.
Masaki Iwasaki; Rei Enatsu; Riki Matsumoto; Eric Novak; Baburaj Thankappen; Zhe Piao; Tim O'Connor; Karl Horning; William Bingaman; Dileep Nair
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Publication Detail:
Type:  Journal Article     Date:  2010-10-18
Journal Detail:
Title:  Epileptic disorders : international epilepsy journal with videotape     Volume:  12     ISSN:  1294-9361     ISO Abbreviation:  Epileptic Disord     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100891853     Medline TA:  Epileptic Disord     Country:  France    
Other Details:
Languages:  eng     Pagination:  292-302     Citation Subset:  IM    
Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
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