| Accentuated antagonism in the control of human heart rate. | |
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MedLine Citation:
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PMID: 10954067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Invasive animal models indicate that the accelerative effects of the sympathetic nervous system on heart rate are highly dependent on the background level of vagal activity. A noninvasive, parasympathetic chronotropic index (respiratory sinus arrhythmia) and a sympathetic chronotropic index (left ventricular ejection time) were used to evaluate autonomic control of human heart rate. A strong interaction, previously called accentuated antagonism, was found. Sympathetic heart rate effects were substantially smaller with high levels of vagal tone than with low vagal background activity. Furthermore, vagal effects became progressively stronger with increasing sympathetic background activity, demonstrating the predominance of parasympathetic control of human heart rate. This finding implies that changes in cardiac activity resulting from changes in sympathetic control cannot be interpreted accurately unless concurrent vagal activity is taken into account, as well. |
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Authors:
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S H Uijtdehaage; J F Thayer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical autonomic research : official journal of the Clinical Autonomic Research Society Volume: 10 ISSN: 0959-9851 ISO Abbreviation: Clin. Auton. Res. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-12-04 Completed Date: 2000-12-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9106549 Medline TA: Clin Auton Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 107-10 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arrhythmia, Sinus / physiopathology Heart Conduction System / physiology* Heart Rate / physiology* Humans Male Models, Cardiovascular Parasympathetic Nervous System / physiology* Respiration Sympathetic Nervous System / physiology* Ventricular Function, Left |
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