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Acceleration of hepatic cholesterol synthesis by triton WR-1339.
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MedLine Citation:
PMID:  13233448     Owner:  NLM     Status:  OLDMEDLINE    
Abstract/OtherAbstract:
Synthesis of cholesterol from acetate in the rat was studied after injection of triton WR-1339, both in the whole animal and by the liver slice technique. Synthesis appeared to be increased 3-fold 24 hours after the injection. It was depressed after 72 hours, concurrently with a rise in the cholesterol concentration in the liver and its fall towards normal in the blood. When triton was injected into cholesterol-fed animals, or when their bile ducts were ligated, cholesterol synthesis was faster than in the untreated, normally fed controls, despite, in some instances, an elevated concentration of cholesterol in the liver.
Authors:
I D FRANTZ; B T HINKELMAN
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  101     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1955 Mar 
Date Detail:
Created Date:  1955-12-01     Completed Date:  2003-05-01     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Cholesterol / metabolism*
Liver / metabolism*
Chemical
Reg. No./Substance:
57-88-5/Cholesterol
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1955, by The Rockefeller Institute for Medical Research New York
Received Day: 26 Month: 10 Year: 1954
Print publication date: Day: 28 Month: 2 Year: 1955
Volume: 101 Issue: 3
First Page: 225 Last Page: 232
ID: 2136468
PubMed Id: 13233448

ACCELERATION OF HEPATIC CHOLESTEROL SYNTHESIS BY TRITON WR-1339
Ivan D. Frantz, Jr.
Beverly T. Hinkelman
From the Cardiovascular Research Laboratory, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston


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