Document Detail


Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation.
MedLine Citation:
PMID:  22257903     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Neural stem cells (NSCs) are highly susceptible to DNA double-strand breaks; however, little is known about the effects of radiation in cells surviving radiation. Although the nestin-positive NSCs predominantly became glial fibrillary acidic protein (GFAP)-positive in differentiation-permissive medium, little or no cells were GFAP positive in proliferation-permissive medium. We found that more than half of the cells surviving X-rays became GFAP positive in proliferation-permissive medium. Moreover, localized irradiation stimulated differentiation of cells outside the irradiated area. These results indicate for the first time that ionizing radiation is able to stimulate astrocyte-specific differentiation of surviving NSCs, whose process is mediated both by the direct activation of nuclear factor-κB and by the indirect bystander effect induced by X-irradiation.
Authors:
Ayumi Ozeki; Keiji Suzuki; Masatoshi Suzuki; Hiroki Ozawa; Shunichi Yamashita
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-16
Journal Detail:
Title:  Neuroreport     Volume:  -     ISSN:  1473-558X     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartment of Radiation Medical Sciences, Atomic Bomb Disease Institute bDepartment of Neuropsychiatry, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
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