Document Detail


Accelerating locomotor recovery after incomplete spinal injury.
MedLine Citation:
PMID:  23531014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A traumatic spinal injury can destroy cells, irreparably damage axons, and trigger a cascade of biochemical responses that increase the extent of injury. Although damaged central nervous system axons do not regrow well naturally, the distributed nature of the nervous system and its capacity to adapt provide opportunities for recovery of function. It is apparent that activity-dependent plasticity plays a role in this recovery and that the endogenous response to injury heightens the capacity for recovery for at least several weeks postinjury. To restore locomotor function, researchers have investigated the use of treadmill-based training, robots, and electrical stimulation to tap into adaptive activity-dependent processes. The current challenge is to maximize the degree of functional recovery. This manuscript reviews the endogenous neural system response to injury, and reviews data and presents novel analyses of these from a rat model of contusion injury that demonstrates how a targeted intervention can accelerate recovery, presumably by engaging processes that underlie activity-dependent plasticity.
Authors:
Brian K Hillen; James J Abbas; Ranu Jung
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1279     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-27     Completed Date:  2013-05-17     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-74     Citation Subset:  IM    
Copyright Information:
© 2013 New York Academy of Sciences.
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MeSH Terms
Descriptor/Qualifier:
Acceleration
Animals
Contusions / pathology,  physiopathology,  rehabilitation
Disease Models, Animal
Humans
Locomotion / physiology*
Models, Biological
Nerve Regeneration / physiology
Rats
Recovery of Function / physiology*
Spinal Cord Injuries / pathology,  physiopathology*,  rehabilitation*
Spinal Injuries / pathology,  physiopathology
Grant Support
ID/Acronym/Agency:
R01 NS054282/NS/NINDS NIH HHS; R01-NS054282/NS/NINDS NIH HHS
Comments/Corrections

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